218799-03-2Relevant articles and documents
Studies in marine macrolide synthesis: Synthesis of a fully functionalised C1-C28 subunit of spongistatin 1 (Altohyrtin A)
Paterson, Ian,Wallace, Debra J.,Oballa, Renata M.
, p. 8545 - 8548 (1998)
The C1-C28 aldehyde 5, containing the AB- and CD-spiroacetal portions together with the bridging chain of spongistatin 1 (1), was prepared. The key step was a lithium-mediated, anti-aldol coupling between ethyl ketone 4 and aldehyde
The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: Fragment couplings, completion of the synthesis, analogue generation and biological evaluation
Paterson, Ian,Chen, David Y.-K.,Coster, Mark J.,Acena, Jose L.,Bach, Jordi,Wallace, Debra J.
, p. 2431 - 2440 (2007/10/03)
The antimitotic marine macrolide altohyrtin A/spongistatin 1 (1) has been synthesised in a highly convergent and stereocontrolled manner, thus contributing to the replenishment of the largely exhausted material from the initial isolation work. Coupling of
Stereocontrolled total synthesis of (+)-altohyrtin A/spongistatin 1
Paterson, Ian,Chen, David Y.-K.,Coster, Mark J.,Acea, Jose L.,Bach, Jordi,Gibson, Karl R.,Keown, Linda E.,Oballa, Renata M.,Trieselmann, Thomas,Wallace, Debra J.
, p. 4055 - 4060 (2007/10/03)
As an exceptionally potent antimitotic macrolide, altohyrtin A/spongistatin 1 shows great promise in cancer chemotherapy but its extreme scarcity in the natural sponges has halted its further preclinical development. A highly stereocontrolled total synthe