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Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 1-(3-bromophenyl)-2-chlorois used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with improved efficacy and selectivity. Ethanone, 1-(3-bromophenyl)-2-chloro-'s reactivity also enables the formation of diverse chemical entities, expanding the scope of drug discovery and development.
Used in Agrochemical Industry:
In the agrochemical industry, Ethanone, 1-(3-bromophenyl)-2-chloroserves as a crucial building block for the synthesis of various agrochemicals. Its incorporation into the molecular structures of these chemicals can enhance their pesticidal properties, leading to more effective and targeted pest control solutions.
Used in Fine Chemicals Industry:
Ethanone, 1-(3-bromophenyl)-2-chlorois also utilized in the synthesis of fine chemicals, which are high-purity chemicals used in various applications such as fragrances, dyes, and specialty chemicals. Its unique structure and reactivity contribute to the development of novel and high-quality fine chemicals.
Used in Material Science:
Ethanone, 1-(3-bromophenyl)-2-chloro-'s potential applications extend to the field of material science, where it can be used in the development of new materials with unique properties. Its reactivity and structural features can be leveraged to create materials with enhanced performance characteristics, such as improved stability, reactivity, or selectivity.

Upstream product

• 186581-53-3 diazomethane 
• 1711-09-7 3-bromobenzoyl chloride 
• 2142-63-4 1-(3-Bromophenyl)ethanone 
• 640733-16-0 1-(3-Bromo-phenyl)-2,2,2-trichloro-ethanol 
• 67-56-1 methanol 
• 2039-86-3 3-bromostyrene 
• 52780-14-0 1-(3-bromophenyl)ethanol 

Relevant academic research and scientific papers

A practical synthesis of α-bromo/iodo/chloroketones from olefins under visible-light irradiation conditions

A practical synthesis of α-bromo/iodo/chloroketones from olefins under visible-light irradiation conditions has been developed. In the presence of PhI(OAc)2 as promoter and under ambient conditions, the reactions of styrenes and triiodomethane undergo the transformation smoothly to deliver the corresponding α-iodoketones without additional photocatalyst in good yields under sunlight irradiation. Meanwhile, the reactions of styrenes with tribromomethane and trichloromethane generate the desired α-bromoketones and α-chloroketones in high yields by using Ru(bpy)3Cl2 as a photocatalyst under blue LED (450–455 nm) irradiation.

Facile Synthesis of α-Haloketones by Aerobic Oxidation of Olefins Using KX as Nonhazardous Halogen Source

An operationally simple and safe synthesis of α-haloketones using KBr and KCl as nonhazardous halogen sources is reported. It involves an iron-catalysed reaction of alkenes with KBr/KCl using O2 as terminal oxidant under the irradiation of visible-light. This strategy avoids the risks associated with handling halo-contained electrophiles (Cl2, Br2, NCS, NBS). The process is tolerant to several functional groups, and extended to a range of substituted styrenes in up to 89% yield. A radical reaction pathway is proposed based on control experiments and spectroscopy studies.

Novel arylalkenylpropargylamines as neuroprotective, potent, and selective monoamine oxidase B inhibitors for the treatment of Parkinson's disease

To develop novel neuroprotective agents, a library of novel arylalkenylpropargylamines was synthesized and tested for inhibitory activities against monoamine oxidases. From this, a number of highly potent and selective monoamine oxidase B inhibitors were identified. Selected compounds were also tested for neuroprotection in in vitro studies with PC-12 cells treated with 6-OHDA and rotenone, respectively. It was observed that some of the compounds tested yielded a marked increase in survival in PC-12 cells treated with the neurotoxins. This indicates that these propargylamines are able to confer protection against the effects of the toxins and may also be considered as novel disease-modifying anti-Parkinsonian agents, which are much needed for the therapy of Parkinson's disease.

NEW ARYLALKENYLPROPARGYLAMINE DERIVATIVES EXHIBITING NEUROPROTECTIVE ACTION FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

The invention relates to novel arylalkenylpropargylamine derivatives of general formula (I) or enantiomers or diastereomers thereof or salts, optionally pharmaceutically acceptable salts, or solvates of any of these. The compounds can be used in treating or preventing a disease or condition in a mammal related to monoamine oxidase dysfunction, especially in neurodegenerative diseases, e.g. Parkinson's disease, Alzheimer's disease or Huntington's disease.

Mild and efficient α-chlorination of carbonyl compounds using ammonium chloride and oxone (2KHSO5·KHSO4· K2SO4)

A simple protocol for the α-monochlorination of ketones and 1,3-dicarbonyl compounds utilizing NH4Cl as a source of chlorine and Oxone as an oxidant in methanol without catalyst is presented. The reaction proceeds at ambient temperature in yields ranging from moderate to excellent.

Copper(I)-promoted synthesis of chloromethyl ketones from trichloromethyl carbinols

(Chemical Equation Presented) Reaction of several trichloromethyl carbinols with 2 equiv of CuCl/bpy in refluxing DCE for 3 h afforded chloromethyl ketones in excellent yield by 1,2-H shift in the copper-chlorocarbenoid intermediate.

One-pot Synthesis of α-chloroketones from Secondary Benzylic Alcohols Using m-Chloroperbenzoic Acid/HCl/DMF System

The one-pot reaction of the oxidation and chlorination of sec-benzylic alcohols by using m-CPBA/HCl/DMF system led to the corresponding α-chloroketones in good yields.

α-Chlorination of Aromatic Acetyl Derivatives with Benzyltrimethylammonium Dichloroiodate

Reaction of aromatic acetyl derivatives with benzyltrimethylammonium dichloroiodate in refluxing dichloroethane/methanol for several hours gave α-chloroacetyl derivatives in good yields.