218898-10-3

Upstream product

• 98-88-4 benzoyl chloride 
• 218898-03-4 2',4',5,7-tetrahydroxy-5'-(3-hydroxy-3-methylbutyl)isoflavone 
• 13246-46-3 2,4-dibenzyloxybenzaldehyde 
• 218898-08-9 2',4',5,7-tetrakis(benzyloxy)-5'-iodoisoflavone 
• 1026735-67-0 1-<4,6-bis(benzyloxy)-2-hydroxyphenyl>-2-<2,4-bis(benzyloxy)-5-iodophenyl>-3,3-dimethoxypropan-1-one 
• 218898-09-0 2',4',5,7-tetrakis(benzyloxy)-5'-(3-hydroxy-3-methyl-1-butynyl)isoflavone 

Downstream Products

• 218898-11-4 2',4',5,7-tetrakis(benzoyloxy)-5'-(3-methyl-2-butenyl)isoflavone 
• 82448-67-7 2',4',5,7-tetrahydroxy-5'-(3-methyl-2-butenyl)isoflavone 
• 96909-24-9 2',4',5,7-tetraacetoxy-5'-(3-methyl-2-butenyl)isoflavone 

Relevant academic research and scientific papers

Regioselective synthesis of prenylisoflavones. Syntheses of allolicoisoflavone A, 2,3-dehydrokievitone, and related compounds

The palladium-catalyzed coupling reaction of 2',4',5,7- tetrakis(benzyloxy)-5'-iodolsoflavone (12), synthesized from the 5- iodochalcone 9, with 2-methyl-3-butyn-2-ol gave the corresponding 5'-(3- hydroxy-3-methyl-1-butynyl)isoflavone 13. The catalytic hydrogenation of 13 gave 2',4',5,7-tetrahydroxy-5'-(3-hydroxy-3-methylbutyl)isoflavone (2). Dehydration of the benzoate 14 of 2 afforded a mixture of 5'-(3-methyl-2- butenyl)isoflavone 15 and the isomer 5'-(3-methyl-3-butenyl)isoflavone 16. The separation of 15 was accomplished by a treatment of the mixture (15 and 16) with mercury(II) nitrate. Hydrolysis of 15 afforded 2',4',5,7- tetrahydroxy-5'-prenylisoflavone (allolicoisoflavone A) (1). In a similar manner, 2',4',5,7-tetrahydroxy-8-prenylisoflavone (2,3-dehydrokievitone) (3) and 2',4',5,7-tetrahydroxy-8-(3-hydroxy-3-methylbutyl)isoflavone (2,3- dehydrokievitone hydrate) (4) were synthesized from the corresponding 8- iodoisoflavone 22. The tetramethyl ether 5 of 3 was also prepared from the 8- iodotetramethoxyisoflavone 32.