218899-31-1

Upstream product

• 917-54-4 methyllithium 
• 218899-29-7 3-{(R)-1-Methyl-2-[1-trimethylsilanyl-meth-(Z)-ylidene]-cyclohexyl}-propionitrile 
• 163877-34-7 (R)-3-(1-methyl-2-oxocyclohexyl)propanenitrile 
• 207725-80-2 3-[(R)-2-(Bromo-trimethylsilanyl-methyl)-2-hydroxy-1-methyl-cyclohexyl]-propionitrile 
• 207725-78-8 3-[(R)-2-Hydroxy-2-(hydroxy-trimethylsilanyl-methyl)-1-methyl-cyclohexyl]-propionitrile 
• 207725-74-4 3-((R)-4-Methyl-2-trimethylsilanyl-1-oxa-spiro[2.5]oct-4-yl)-propionitrile 

Relevant academic research and scientific papers

Artemisinin tricyclic analogs: Role of a methyl group at C-5a

New artemisinin tricyclic analogs, bearing a methyl group at C-5a were synthetized through ozonation of vinylsilanes. Presence of such a substituent was detrimental to the antimalarial activity of these trioxanes, thus reinforcing the hypothesis that tight hemin-trioxane complexes are involved in the activation phase of these compounds.