207725-74-4

Basic information

• Product Name: 3-((R)-4-Methyl-2-trimethylsilanyl-1-oxa-spiro[2.5]oct-4-yl)-propionitrile
• Synonyms: 3-((R)-4-Methyl-2-trimethylsilanyl-1-oxa-spiro[2.5]oct-4-yl)-propionitrile
• CAS NO: 207725-74-4
• Molecular Weight: 251.444
• Mol File: 207725-74-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-((R)-4-Methyl-2-trimethylsilanyl-1-oxa-spiro[2.5]oct-4-yl)-propionitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-((R)-4-Methyl-2-trimethylsilanyl-1-oxa-spiro[2.5]oct-4-yl)-propionitrile(207725-74-4)
• EPA Substance Registry System: 3-((R)-4-Methyl-2-trimethylsilanyl-1-oxa-spiro[2.5]oct-4-yl)-propionitrile(207725-74-4)

Safety Data

• Hazardous Substances Data: 207725-74-4(Hazardous Substances Data)

Upstream product

• 163877-34-7 (R)-3-(1-methyl-2-oxocyclohexyl)propanenitrile 
• 63830-85-3 chloro(trimethylsilyl)methyl lithium 

Downstream Products

• 218899-31-1 4-{(R)-1-Methyl-2-[1-trimethylsilanyl-meth-(Z)-ylidene]-cyclohexyl}-butan-2-one 
• 218899-29-7 3-{(R)-1-Methyl-2-[1-trimethylsilanyl-meth-(Z)-ylidene]-cyclohexyl}-propionitrile 
• 207725-80-2 3-[(R)-2-(Bromo-trimethylsilanyl-methyl)-2-hydroxy-1-methyl-cyclohexyl]-propionitrile 
• 207725-78-8 3-[(R)-2-Hydroxy-2-(hydroxy-trimethylsilanyl-methyl)-1-methyl-cyclohexyl]-propionitrile 

Relevant articles and documents

Artemisinin tricyclic analogs: Role of a methyl group at C-5a

New artemisinin tricyclic analogs, bearing a methyl group at C-5a were synthetized through ozonation of vinylsilanes. Presence of such a substituent was detrimental to the antimalarial activity of these trioxanes, thus reinforcing the hypothesis that tight hemin-trioxane complexes are involved in the activation phase of these compounds.