218899-45-7

Upstream product

• 218899-34-4 5-[5,7-Dimethoxy-3-(4-methoxy-phenyl)-4-oxo-4H-chromen-2-yl]-pentanoic acid methyl ester 
• 15485-65-1 2,4,4',6-tetrahydroxydeoxybenzoin 
• 35444-44-1 methyl adipoyl chloride 
• 627-91-8 adipic acid monomethyl ester 
• 218899-20-8 Hexanedioic acid 3,5-dimethoxy-2-[2-(4-methoxy-phenyl)-acetyl]-phenyl ester methyl ester 

Relevant academic research and scientific papers

An expedient synthesis of 2-(ω-carboxyalkyl)polyhydroxyisoflavones

Derivatives of the isoflavones daidzein and genistein, carrying a carboxyalkyl attachment at C-2 were prepared by cyclization of unprotected 2,4,4'-trihydroxy- or 2,4,4',6-tetrahydroxydeoxybenzoin in the presence of a number of 1,ω-alkanedicarboxylic acid monoester monochlorides, K2CO3 and a phase-transfer catalyst in dry acetone. Hydrolysis under basic conditions of the resulting 2-(ω-alkoxycarbonylalkyl)isoflavones gives the title compounds, useful for developing RIA techniques for the analysis of the parent isoflavones.

A facile synthesis of 2-substituted isoflavones for immunoassay: Assembly of the isoflavonoid skeleton by means of a novel cyclisation reaction

For the purpose of the development of immunoassays for wide-scale screening, isoflavones suitable for attachment to a hapten were prepared. A new cyclisation reaction allowed the direct conversion of 2- (acyloxy)deoxybenzoins to 2-alkylisoflavones by treatment with chlorotrimethylsilane and triethylamine in dimethylformamide.