2189-33-5

Upstream product

• 144451-87-6 3,3-bis(4-chlorophenyl)-2-cyanopropanoic acid 
• 101446-71-3 3,3-Bis-(4-chloro-phenyl)-2-cyano-propionic acid methyl ester 
• 105358-33-6 3,3-bis-(4-chloro-phenyl)-propionamide 
• 2172-50-1 3,3-bis-(4-chloro-phenyl)-propionitrile 
• 90-98-2 4,4'-Dichlorobenzophenone 
• 1071466-43-7 3,3-bis(4-chlorophenyl)-2-propenenitrile 
• 104-88-1 4-chlorobenzaldehyde 
• 54440-99-2 methyl 2-cyano-3-(4-chlorophenyl)propenoate 

Downstream Products

• 102311-16-0 isonicotinic acid-[3,3-bis-(4-chloro-phenyl)-propylamide] 
• 144290-57-3 N-Benzoyl-N'-[3,3-bis-(4-chloro-phenyl)-propyl]-N''-[3-(1H-imidazol-4-yl)-propyl]-guanidine 
• 144478-07-9 N-[3,3-Bis-(4-chloro-phenyl)-propyl]-N'-[3-(1H-imidazol-4-yl)-propyl]-guanidine; hydrochloride 
• 102592-34-7 2-ethylmercapto-6-chloro-isonicotinic acid-[3,3-bis-(4-chloro-phenyl)-propylamide] 
• 102592-35-8 2-ethoxy-6-chloro-isonicotinic acid-[3,3-bis-(4-chloro-phenyl)-propylamide] 

Relevant academic research and scientific papers

Silver-Catalyzed Long-Distance Aryl Migration from Carbon Center to Nitrogen Center

Selective cleavage of an inert C-C bond followed by C-O/N bond formation through a long-distance aryl migration from a carbon to a nitrogen center via Ag catalysis is reported. The migration products were easily converted into γ-hydroxy amines and tetrahy

N-SUBSTITUTED PYRIDINONE OR PYRIMIDINONE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS

Disclosed are compounds of the formula (I) with the definitions of A1 D, Q, W, X, Y and Z as indicated in the description, which are active against soluble epoxide hydrolase (sEH), compositions thereof and methods of using and making same. (I)

Soluble Epoxide Hydrolase Inhibitors and Methods of Using Same

Disclosed are compounds active against soluble epoxide hydrolase (sEH), compositions thereof and methods of using and making same.

Synthesis and histamine H2 agonistic activity of arpromidine analogues: replacement of the pheniramine-like moiety by non-heterocyclic groups

Analogues of the potent histamine H2 agonist arpromidine, characterized by non-hetrocyclic groups (phenyl, cyclohexyl, alkyl) instead of the pheniramine-like portion, were prepared and tested for their H2 agonistic and H1 antagonistic activity in the isolated guiea pig right atrium and ileum, respectively.In the diphenylpropylguanidine series an increase in H2 agonistic potency resulted from mono- or difluorination at one or both phenyl rings in the meta and/or para position (pD2 7.75 vs pD2 = 7.15 for the unsubstituted parent compound).Compounds chlorinated atboth phenyl rings were considerably less potent.Highest combined H2 agonistic/H1 antagonistic potency was found in the 4-fluorophenyl series.The arpromidine analogue with cyclohexyl and methyl group instead of phenyl and pyridine ring proved to be 30 times more potent than histamine in the atrium.The H1 antagonistic potency in cyclohexyl compounds was lower than in the diaryl series.Thus, aromatic rings appear not to be required for high H2 agonistic potency but are useful for combined H2 agonistic/H1 antagonistic activity. histamine / H2 receptor / H2 agonist / arpromidine / impromidine / H1 antagonist / antihistamine