54440-99-2

Upstream product

• 67-56-1 methanol 
• 69727-07-7 3-(4-chlorophenyl)-2-cyanoacrylic acid 
• 104-88-1 4-chlorobenzaldehyde 
• 105-34-0 methyl 2-cyanoacetate 
• 109520-78-7 2-(4-chlorophenyl)-1,1,-dinitroethene 
• 2286-35-3 ethyl 3-(4-chlorophenyl)-2-cyanoacrylate 
• 3395-81-1 4-chlorobenzaldehyde dimethyl acetal 
• 107-91-5 cyanoacetic acid amide 

Downstream Products

• 144451-64-9 3-(4-Chloro-phenyl)-2-cyano-3-(3-fluoro-phenyl)-propionic acid methyl ester 
• 101446-71-3 3,3-Bis-(4-chloro-phenyl)-2-cyano-propionic acid methyl ester 
• 144451-67-2 3-(4-Chloro-phenyl)-2-cyano-3-(3,4-difluoro-phenyl)-propionic acid methyl ester 
• 189697-36-7 methyl 2-cyano-3-(4-chlorophenyl)propionate 
• 1199874-11-7 methyl 3-(4-chlorophenyl)-2-cyano-3-(1H-pyrrol-2-yl)propanoate 

Relevant academic research and scientific papers

Synthesis, characterization and application of α-Ca3 (PO4)2 as a heterogeneous catalyst for the synthesis of 2.3-diphenylquinoxaline derivatives and knoevenagel condensation under green conditions

Green chemistry is now paramount in modern life and industrial sector. It has become a research priority and a scientific challenge. In this study, alpha-tricalcic phosphate was prepared as a green catalytic medium. This medium has been characterized by v

Bis [hydrazinium (1+)] hexafluoridosilicate:(N2H5)2SiF6 novel hybrid crystal as an efficient, reusable and environmentally friendly heterogeneous catalyst for Knoevenagel condensation and synthesis of biscoumari

A simple, effective, green and nontoxic protocol was used for the Knoevenagel condensation and the biscoumarin derivatives synthesis. It have demonstrated that the use of a new hybrid crystal as a heterogeneous catalyst makes it possible to obtain several

Direct Cyclopropanation of α-Cyano β-Aryl Alkanes by Light-Mediated Single Electron Transfer Between Donor–Acceptor Pairs

Cyclopropanes are traditionally prepared by the formal [2+1] addition of carbene or radical based C1 units to alkenes. In contrast, the one-pot intermolecular cyclopropanation of alkanes by redox active C1 units has remained unrealised. Herein, we achieve

A Tailored Heptazine-Based Porous Polymeric Network as a Versatile Heterogeneous (Photo)catalyst

A heptazine-based microporous polymeric network, HMP-TAPA was synthesised by direct coupling of trichloroheptazine and tris(4-aminophenyl)amine (TAPA). A high surface area of 424 m2/g was achieved, which is the highest surface area among heptaz

One-Pot Synthesis of γ-Azidobutyronitriles and Their Intramolecular Cycloadditions

Efficient gram-scale, one-pot approaches to azidocyanobutyrates and their amidated or decarboxylated derivatives have been developed, starting from commercially available aldehydes and cyanoacetates. These techniques combine (1) Knoevenagel condensation,

Diastereoselective Synthesis of Spiro[2.3]hexanes from Methylenecyclopropane and Cyanoalkenes Catalyzed by a Tin-Ate Complex

A diastereoselective synthesis of spiro[2.3]hexane catalyzed by Sn and Mg halides was developed from a combination of methylenecyclopropane and cyanoalkene bearing an ester group. The selectivity was affected by the size of the halogen in the catalyst and

Green and efficient synthesis method for aryl acrylonitrile compound

The invention discloses a green and efficient synthesis method for an aryl acrylonitrile compound represented by formula III. The method comprises the following steps: in an air atmosphere, by takingaryl acetonitrile of formula I as shown in the specification and excess methyl cyanoacetate of formula II as shown in the specification as raw materials, and Ru/C as a catalyst, enabling the components to react at 150-160 DEG C in the absence of a solvent, and separating and purifying a reaction mixture obtained after the reaction is completed, thereby obtaining an aryl acrylonitrile compound of formula III as shown in the specification. The method disclosed by the invention is not only low in production cost, but also good in environment protection, and is very applicable to industrial large-scale production.

Synthesis, antiproliferative and pro-apoptotic effects of nitrostyrenes and related compounds in Burkitt’s lymphoma

Background: Cancers of the lymphatic cells (lymphomas) account for approximately 12% of malignant diseases worldwide. The nitrostyrene scaffold is identified as a lead target structure for the development of particularly effective compounds targeting Burkitt’s lymphoma (BL). Objectives: The aims of the curent study were to synthesise a panel of nitrostyrene compounds and to evaluate their activity in Burkitt’s lymphoma (BL). Methods: A panel of structurally varied compounds were designed and synthesised using Henry Knoevenagel condensation reactions. Single crystal X-Ray analysis confirmed the E configuration for six examples of these novel structures. A number of nitrostyrene-related compounds were also investigated including 1,3-bis(aryl)-2-nitropropenes together with heterocyclic scaffolds containing the nitrovinyl pharmacophore such as 3-nitro-2-phenyl-2H-chromenes. The antiproliferative activities of the compounds were evaluated using the BL cell lines EBV- MUTU-1 and EBV+ DG-75 (chemoresistant) to establish preliminary structure-activity relationships. Results: Lead compounds with optimized nitrostyrene scaffolds and 3-nitro-2-phenyl-2Hchromene structures were successfully established with typical IC50 values of 0.45 μM and 0.47 μM in MUTU-1 cells and 1.41 μM and 1.92 μM, respectively, in DG-75 cells. The mechanism of cell death was identified as apoptotic and the lead compound was found to elicit comparable apoptotic effects to Taxol in Burkitt’s lymphoma cell lines MUTU-1 and DG-75. Conclusion: This class of pharmaceutically active compounds with potential for the treatment of Burkitt’s lymphoma suggest a potential role for nitrostyrene based agents in chemotherapy.

Microporous polyurethane material for size selective heterogeneous catalysis of the Knoevenagel reaction

The first polyurethane material which is microporous (BET surface area of 312 m2 g-1) is prepared by solvothermal synthesis and acts as highly efficient and recyclable heterogeneous catalyst in the Knoevenagel condensation showing si