218900-56-2

Basic information

• Product Name: TERT-BUTYL [(1S)-1-(3-METHOXYPHENYL)ETHYL]CARBAMATE
• Synonyms: TERT-BUTYL [(1S)-1-(3-METHOXYPHENYL)ETHYL]CARBAMATE
• CAS NO: 218900-56-2
• Molecular Formula: C₁₄H₂₁NO₃
• Molecular Weight: 251.32144
• Mol File: 218900-56-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: TERT-BUTYL [(1S)-1-(3-METHOXYPHENYL)ETHYL]CARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL [(1S)-1-(3-METHOXYPHENYL)ETHYL]CARBAMATE(218900-56-2)
• EPA Substance Registry System: TERT-BUTYL [(1S)-1-(3-METHOXYPHENYL)ETHYL]CARBAMATE(218900-56-2)

Safety Data

• Hazardous Substances Data: 218900-56-2(Hazardous Substances Data)

Usage

General Description

TERT-BUTYL [(1S)-1-(3-METHOXYPHENYL)ETHYL]CARBAMATE is a chemical compound commonly used in pharmaceuticals and research due to its carbamate functional group, which has been shown to exhibit various biological activities. It is a tert-butyl carbamate derivative of (1S)-1-(3-methoxyphenyl)ethylamine, possessing a tert-butyl group linked to the nitrogen atom and an ethyl group linked to the carbon atom. TERT-BUTYL [(1S)-1-(3-METHOXYPHENYL)ETHYL]CARBAMATE is often utilized in the synthesis of potential drug candidates or as a building block in organic chemistry reactions. Additionally, its structure and properties make it a valuable tool for investigating the structure-activity relationships of different pharmaceutical targets.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 50919-07-8 (S)-1-(3-methoxyphenyl)ethylamine 

Downstream Products

• 266369-42-0 (S)-[1-(3-hydroxyphenyl)ethyl]carbamic acid tert-butyl ester 
• 123441-03-2 rivastigmin 
• 139306-10-8 (S)-3-(1-dimethylaminoethyl)phenol 
• 889443-69-0 S-(-)-[1-(3-methoxyphenyl)ethyl]-N,N-dimethylamine 
• 63720-38-7 3-hydroxy-(S)-α-phenethylamine 

Relevant articles and documents

Group-assisted Purification (GAP) Chemistry/Technology in synthesizing the chiral intermediate of rivastigmine and its ?-Alkyl benzylamine analogues

Introduction of (S)-configuration is the key step in the synthesis of the anti-dementia drug Rivastigmine. Twenty-one alkylation products were obtained through simple washing with hexane/ethyl acetate (v/v: 10/1) in good yields (>85%) and high diastereoselectivity (up to >99:1 dr). Moreover, the chiral auxiliary could be easily dissociated and readily regenerated. That is, the synthesis was proved to follow group-assisted purification (GAP) chemistry/technology. In addition, the chiral amine produced by this asymmetric alkylation reaction was effectively used in the synthesis of Rivastigmine.

NOVEL N-PYRAZINIL-PHENYLSULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS FOR USE IN THE TREATMENT OF ASTHMA

The invention provides a compound of formula (I), wherein R1, R2 and R3 are as defined in the specification, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy.