266369-42-0

Basic information

• Product Name: TERT-BUTYL [(1S)-1-(3-HYDROXYPHENYL)ETHYL]CARBAMATE
• Synonyms: TERT-BUTYL [(1S)-1-(3-HYDROXYPHENYL)ETHYL]CARBAMATE
• CAS NO: 266369-42-0
• Molecular Formula: C₁₃H₁₉NO₃
• Molecular Weight: 237.29486
• Mol File: 266369-42-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 387.3±25.0 °C(Predicted)
• Appearance: /
• Density: 1.096±0.06 g/cm3(Predicted)
• PKA: 9.84±0.10(Predicted)
• CAS DataBase Reference: TERT-BUTYL [(1S)-1-(3-HYDROXYPHENYL)ETHYL]CARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL [(1S)-1-(3-HYDROXYPHENYL)ETHYL]CARBAMATE(266369-42-0)
• EPA Substance Registry System: TERT-BUTYL [(1S)-1-(3-HYDROXYPHENYL)ETHYL]CARBAMATE(266369-42-0)

Safety Data

• Hazardous Substances Data: 266369-42-0(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 63720-38-7 3-hydroxy-(S)-α-phenethylamine 
• 50919-07-8 (S)-1-(3-methoxyphenyl)ethylamine 
• 218900-56-2 (S)-[1-(3-methoxyphenyl)ethyl]carbamic acid tert-butyl ester 

Downstream Products

• 931093-13-9 [(1S)-1-[3-[[5-[[2,3-dichlorobenzenesulphonyl]-[[2-[trimethylsilanyl]ethoxy]methyl]amino]-6-methoxypyrazinyl]oxy]phenyl]ethyl]carbamic acid, 1,1-dimethylethyl ester 
• 931093-14-0 [(1S)-1-[3-[[5-[[(2,3-dichlorobenzene)sulphonyl][[2-(trimethylsilanyl)ethoxy]methyl]amino]-6-methoxy-3-methylpyrazinyl]oxy]phenyl]ethyl]carbamic acid, 1,1-dimethylethyl ester 
• 266369-43-1 tert-butyl (1S)-(-)-1-[3-(5-chloro-2-nitrophenoxy)phenyl]ethylcarbamate 
• 477312-35-9 (S)-[1-(3-morpholin-4-yl-phenyl)ethyl]-carbamic acid tert-butyl ester 
• 477312-33-7 (S)-trifluoromethanesulfonic acid 3-(1-tert-butoxycarbonylamino-ethyl)-phenyl ester 

Relevant articles and documents

3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH

The invention is directed to a formula (I), or a pharmamceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.

NOVEL N-PYRAZINIL-PHENYLSULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS FOR USE IN THE TREATMENT OF ASTHMA

The invention provides a compound of formula (I), wherein R1, R2 and R3 are as defined in the specification, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy.

AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME

Compounds of a formula: wherein Ring A represents an optionally-substituted aromatic ring; Ring B represents an optionally-substituted cyclic hydrocarbon group; Z represents an optionally-substituted cyclic group; R1 represents a hydrogen atom, an optionally-substituted hydrocarbon group, an optionally-substituted heterocyclic group, or an acyl group; R2 represents an optionally-substituted amino group; D represents a chemical bond or a divalent group; E represents -CO-, -CON(Ra)-, COO-, -N(Ra)CON(Rb)-, -N(Ra)COO-, -N(Ra)SO2-, -N(Ra)-, -O-, -S-,-SO- or -SO2- (in which Ra and Rb each independently represent a hydrogen atom or an optionally-substituted hydrocarbon group); G represents a chemical bond or a divalent group; L represents (1) a chemical bond or (2) a divalent hydrocarbon group optionally having from 1 to 5 substituents selected from;(i) a C1-6 alkyl group,(ii) a halogeno-C1-6 alkyl group,(iii) a phenyl group,(iv) a benzyl group,(v) an optionally-substituted amino group,(vi) an optionally-substituted hydroxy group, and(vii) a carbamoyl or thiocarbamoyl group optionally substituted by: a C1-6 alkyl group, an optionally-substituted phenyl group, or an optionally-substituted heterocyclic group, and optionally interrupted by -O- or -S-; X represents an oxygen atom, an optionally-oxidized sulfur atom, an optionally-substituted nitrogen atom, or an optionally-substituted divalent hydrocarbon group; Y represents two hydrogen atoms, an oxygen atom or a sulfur atom; .... means that R2 may be bonded to the atom on Ring B to form a ring, or their salts, and a method for producing them.