218934-27-1Relevant academic research and scientific papers
Tandem radical cyclisation and translocation approaches to biologically important mitomycin ring systems
Allan, Gillian M.,Parsons, Andrew F.,Pons, Jean-Fran?ois
, p. 1431 - 1434 (2007/10/03)
New free-radical cyclisation and translocation approaches to the tricyclic mitomycin ring system have been developed. These convergent approaches involve either a tandem 5-endo/5-exo radical cyclisation or alternatively, a 1,6-hydrogen-atom transfer follo
Neighbourgroup Participation with the Dehydrogenation of Cyclic Amines of the o-Substituted Aniline Type
Moehrle,Mehrens
, p. 1369 - 1378 (2007/10/03)
The 2-Aminobenzylalcohols 1a - c produced with mercury-edta dehydrogenation the lactams 6a - c; the pipecoline 2b yielded the benzoxazine 3b indicating the participation of the nucleophilic hydroxymethyl group. The 2-aminobenzaldehydes showed a different behaviour in dependence on the ring size of the amine part: 7a, b led - via intermediate reaction of the hemiaminal 9 with the electrophilic formyl function - to the lactams 11a, b, while 7c gave rise to the aminoaldehyde 12 as major product and similarly the pipecoline 15 to the aminoketone 16. From 2′-(4-morpholinyl)-acetophenone (22) were received the lactam 31 and the aminoethanol 32, both by a twofold dehydrogenation.
