218940-65-9Relevant academic research and scientific papers
A 1 - (substituted phenyl) -4 - methyl piperazine of the preparation process
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Paragraph 0066-0069, (2019/07/01)
The invention discloses a 1 - (substituted phenyl) - 4 - methyl piperazine of the preparation process, the process of the invention preparation method to 1 - (substituted phenyl) - piperazine compound A - 1 as a raw material, in the presence of acetic aci
Microwave-assisted amination from fluorobenzenes without catalyst and strong base
Meng, Xiangguo,Cai, Zhengyan,Xiao, Sa,Zhou, Weicheng
, p. 70 - 75 (2013/03/14)
A facile and versatile amination of fluorobenzenes has been developed in good to excellent yields under microwave irradiation in N-methylpyrrolidinone (NMP) without strong base and catalyst. The presence of additional halogen atom(s) enhanced the leaving ability of fluorine and meta fluorine gave higher activation than the ortho. It is remarkable that 1,2,3-trifluorobenzene, 1,2,4-trifluorobenzene and 1,2,4,5-tetrafluorobenzene can produce the regioselective mono-substituted products.
