21905-97-5

Basic information

• Product Name: 3-(3-Chlorophenyl)-2-butanone
• Synonyms: 3-(3-Chlorophenyl)-2-butanone;3-(3-Chlorophenyl)butan-2-one
• CAS NO: 21905-97-5
• Molecular Formula: C₁₀H₁₁ClO
• Molecular Weight: 182.64674
• Mol File: 21905-97-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(3-Chlorophenyl)-2-butanone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-Chlorophenyl)-2-butanone(21905-97-5)
• EPA Substance Registry System: 3-(3-Chlorophenyl)-2-butanone(21905-97-5)

Safety Data

• Hazardous Substances Data: 21905-97-5(Hazardous Substances Data)

Upstream product

• 1758-32-3 2,3-epoxybutane 
• 108-37-2 1-bromo-3-chlorobenzene 
• 587-04-2 m-Chlorobenzaldehyde 
• 19394-34-4 (E)-1-(3'-chlorophenyl)-2-nitropropene 
• 14123-60-5 3-chlorophenylacetone 
• 74-88-4 methyl iodide 

Downstream Products

• 1070875-06-7 N-(1-(3-chlorophenyl)ethyl)acetamide 
• 1372209-61-4 C₈H₈ClN₃ 
• 120121-01-9 1-(m-Chlorophenyl)ethanol 
• 1262155-52-1 C₂₀H₁₈ClNO₃S 
• 1309380-77-5 3-(m-chlorophenyl)-2-butanone oxime 
• 1173092-38-0 (R)-3-(3-chlorophenyl)butan-2-one 
• 1103679-61-3 (S)-1-(3-chlorophenyl)ethanol acetate 
• 63099-38-7 Trifluoro-methanesulfonic acid (E)-2-(3-chloro-phenyl)-1-methyl-propenyl ester 
• 63099-44-5 Trifluoro-methanesulfonic acid (Z)-2-(3-chloro-phenyl)-1-methyl-propenyl ester 
• 20110-25-2 2-(m-Chlorphenyl)-3-butylamin 

Relevant articles and documents

Baeyer-Villiger monooxygenase-catalyzed kinetic resolution of racemic α-alkyl benzyl ketones: enzymatic synthesis of α-alkyl benzylketones and α-alkyl benzylesters

The application of three BVMOs for the enantioselective oxidation of 3-phenylbutan-2-ones with different substituents in the aromatic moiety is described. By choosing the appropriate biocatalyst and substrate combination, chiral ketones and esters can be obtained with excellent enantiopurities. This methodology could also be applied to the resolution of racemic α-alkyl benzylketones with longer alkyl chains as well as with two substituted α-substituted benzylacetones. A kinetic analysis revealed that the BVMOs studied effectively convert all tested compounds showing that the enzymes are tolerant towards the substrate structure while being highly enantioselective. These properties render BVMOs as valuable biocatalysts for the preparation of compounds with high interest in organic synthesis.