1103679-61-3

Basic information

• Product Name: (S)-1-(3-chlorophenyl)ethanol acetate
• Synonyms: (S)-1-(3-chlorophenyl)ethanol acetate
• CAS NO: 1103679-61-3
• Molecular Weight: 198.649
• Mol File: 1103679-61-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (S)-1-(3-chlorophenyl)ethanol acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(3-chlorophenyl)ethanol acetate(1103679-61-3)
• EPA Substance Registry System: (S)-1-(3-chlorophenyl)ethanol acetate(1103679-61-3)

Safety Data

• Hazardous Substances Data: 1103679-61-3(Hazardous Substances Data)

Upstream product

• 120121-01-9 1-(m-Chlorophenyl)ethanol 
• 108-24-7 acetic anhydride 
• 19759-26-3 (+/-)-1-(3-chlorophenyl)ethyl acetate 
• 22391-00-0 α-Acetoxy-m-chloro-styrol 
• 876-27-7 4-chlorophenyl acetate 
• 21905-97-5 3-(3-chlorophenyl)butan-2-one 

Relevant articles and documents

Separation of enantiopure m-substituted 1-phenylethanols in high space-time yield using Bacillus subtilis esterase

A recombinant Bacillus subtilis esterase (BsE) expressed in E. coli was found to exhibit excellent enantioselectivity (E was always greater than 100) towards m-substituted 1-phenylethanol acetates in the enantioselective hydrolysis reaction. An explanation for the high enantioselectivity observed towards these substrates was provided by molecular modeling. Moreover, the BsE also showed strong tolerance towards a high concentration of m-substituted 1-phenylethanol acetates (up to 1 M). Based on these excellent catalytic properties of BsE, a kind of m-substituted 1-phenylethanols, (R)-1-(3-chlorophenyl)ethanol, was efficiently synthesized in space-time yield of 920 g per L per day and 97% ee, indicating that the BsE was considered as a potentially ideal and promising biocatalyst for large-scale production of optically active m-substituted 1-phenylethanols. The Royal Society of Chemistry 2013.

Rh(I)/DpenPhos catalyzed asymmetric hydrogenation of enol esters and potassium (E)-3-cyano-5-methylhex-3-enoate

Rh(I) complexes of a class of modular chiral monodentate phosphoramidites were highly efficient for the asymmetric hydrogenation of enol esters bearing α-aryl or α-alkyl groups, to afford the corresponding hydrogenation products in high enantioselectiviti

Baeyer-Villiger monooxygenase-catalyzed kinetic resolution of racemic α-alkyl benzyl ketones: enzymatic synthesis of α-alkyl benzylketones and α-alkyl benzylesters

The application of three BVMOs for the enantioselective oxidation of 3-phenylbutan-2-ones with different substituents in the aromatic moiety is described. By choosing the appropriate biocatalyst and substrate combination, chiral ketones and esters can be obtained with excellent enantiopurities. This methodology could also be applied to the resolution of racemic α-alkyl benzylketones with longer alkyl chains as well as with two substituted α-substituted benzylacetones. A kinetic analysis revealed that the BVMOs studied effectively convert all tested compounds showing that the enzymes are tolerant towards the substrate structure while being highly enantioselective. These properties render BVMOs as valuable biocatalysts for the preparation of compounds with high interest in organic synthesis.