21909-45-5

Basic information

• Product Name: 5-Amino-1-benzylindoline
• Synonyms: 5-Amino-1-benzylindoline;1-benzylindolin-5-amine;1H-INDOL-5-AMINE,2,3-DIHYDRO-1-(PHENYLMETHYL)-;1-benzyl-2,3-dihydroindol-5-amine
• CAS NO: 21909-45-5
• Molecular Formula: C₁₅H₁₆N₂
• Molecular Weight: 224.3
• Mol File: 21909-45-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Amino-1-benzylindoline(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-1-benzylindoline(21909-45-5)
• EPA Substance Registry System: 5-Amino-1-benzylindoline(21909-45-5)

Safety Data

• Hazardous Substances Data: 21909-45-5(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 32692-19-6 5-nitro-2,3-dihydro-1H-indole 
• 227956-83-4 1-benzyl-5-nitro-2,3-dihydro-1H-indole 

Downstream Products

• 741692-09-1 (S)-2-[3-(1-Benzyl-2,3-dihydro-1H-indol-5-yl)-ureido]-4-methyl-pentanoic acid ((S)-2-oxo-tetrahydro-furan-3-yl)-amide 
• 741692-06-8 2-[3-(1-benzyl-2,3-dihydro-1H-indol-5-yl)-ureido]-4-methyl-pentanoic acid 
• 848133-83-5 6-amino-4-(1-benzyl-2,3-dihydro-1H-indol-5-ylamino)-7-ethoxyquinoline-3-carbonitrile 
• 1025997-45-8 N-[4-(1-benzyl-2,3-dihydro-1H-indol-5-ylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-acetamide 
• 741692-03-5 2-[3-(1-benzyl-2,3-dihydro-1H-indol-5-yl)-ureido]-4-methyl-pentanoic acid methyl ester 

Relevant articles and documents

Indole derivatives or salts thereof as well as preparation method and application of indole derivatives or salts thereof

The invention belongs to the technical field of chemical medicine, and relates to an Hh (Hedgehog) signal pathway Smoothed (SMO) receptor small molecule inhibitor, in particular to indole derivativesor salts thereof with Smoothed inhibitory activity, which are shown in chemical general formula (I) in the description, as well as a preparation method and pharmaceutical composition of the indole derivatives or salts thereof. Tests on inhibitory activity of Hh signal pathways show that most compounds have better inhibitory activity on the Hh signal pathways. The invention further discloses the application of the compounds to preparation of medicines for treating diseases associated with Hh, wherein the diseases are BCC (basal cell carcinoma), MB (medullblastoma), SCLC (small cell lung cancer), medulloblastoma, rhabdomyosarcoma, or a combination of the diseases.

Novel dual inhibitors of calpain and lipid peroxidation

A series of molecules with dual inhibitory activities on calpain and lipid peroxidation were synthesized. These hybrid compounds were built on the calpain pharmacophore 2-hydroxytetrahydrofuran linked to a set of antioxidants via a L-leucine linker. Compo