21914-07-8

Basic information

• Product Name: 5,5-diphenylbarbituric acid
• Synonyms: 5,5-diphenylbarbituric acid;5,5-DIPHENYLBARBITURIC ACID(WXG01726)
• CAS NO: 21914-07-8
• Molecular Formula: C₁₆H₁₂N₂O₃
• Molecular Weight: 280.28
• Mol File: 21914-07-8.mol

Chemical Properties

• Boiling Point: 423.01°C (rough estimate)
• Appearance: /
• Density: 1.1913 (rough estimate)
• Refractive Index: 1.5800 (estimate)
• Water Solubility: 17.85mg/L(temperature not stated)
• CAS DataBase Reference: 5,5-diphenylbarbituric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5,5-diphenylbarbituric acid(21914-07-8)
• EPA Substance Registry System: 5,5-diphenylbarbituric acid(21914-07-8)

Safety Data

• Hazardous Substances Data: 21914-07-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5,5-diphenylbarbituric acid is used as an intermediate in the synthesis of barbiturate drugs for its sedative and hypnotic properties. It contributes to the development of medications that act as central nervous system depressants, providing therapeutic benefits in the treatment of anxiety, insomnia, and seizures.
Used in Organic Synthesis:
5,5-diphenylbarbituric acid serves as a reactant in organic synthesis, enabling the creation of various chemical compounds with potential applications in different industries.
Used in Research and Development:
As a research chemical, 5,5-diphenylbarbituric acid is utilized in the study of barbiturate drugs and their effects on the central nervous system. This research aids in understanding the mechanisms of action, potential side effects, and the development of safer and more effective medications.

InChI:InChI=1/C16H12N2O3/c19-13-16(11-7-3-1-4-8-11,12-9-5-2-6-10-12)14(20)18-15(21)17-13/h1-10H,(H2,17,18,19,20,21)

Upstream product

• 3237-50-1 5,5-dihydroxy-pyrimidine-2,4,6-trione 
• 71-43-2 benzene 
• 57-13-6 urea 
• 29548-99-0 2,2-diphenylmalonyl dichloride 
• 67-52-7 BARBITURIC ACID 
• 3076-54-8 phenyllead(IV) triacetate 
• 7664-93-9 sulfuric acid 
• 97846-21-4 N,N'-bismethoxymethyl-5,5-diphenyl-barbituric acid 
• 876481-99-1 diphenyl-malonic acid diamide 

Downstream Products

• 81498-89-7 (diphenylacetyl)urea 
• 132660-05-0 2-<5'-(Dimethylamino)-4',4'-dimethyl-4'H-imidazol-2'-yl>-2,2-diphenylacetamid 
• 97846-21-4 N,N'-bismethoxymethyl-5,5-diphenyl-barbituric acid 
• 888711-26-0 5,5-diphenyl barbituric acid potassium salt 
• 888711-28-2 5,5-diphenyl barbituric acid lithium salt 
• 57-30-7 sodium phenobarbital 

Relevant articles and documents

Process for preparing 1-methoxymethyl-5,5-diphenylbarbituric acid

The present invention provides a novel process for preparing 1-methoxymethyl-5,5-diphenylbarbituric acid. In particular, the present invention provides a process for preparing 1-methoxymethyl-5,5-diphenylbarbituric acid by reacting 1,3-bis(methoxymethyl)-

The Chemistry of Aryllead(IV) Tricarboxylates. Reaction with Derivatives of Malonic Acid: New Routes to α-Aryl Carboxylic Acids and Arylated Barbituric Acid Derivatives

Derivatives of 2,2-dimethyl-1,3-dioxan-4,6-dione (Meldrum's acid) and the sodium salts of substituted malonic esters undergo electrophilic C-arylation in high yield with aryllead triacetates, thus providing new routes to α-arylalkanoic acids.Syntheses of the antiflammatory compound 2-(p-isobutylphenyl)propanoic acid (Ibuprofen) have been carried out to demonstrate the method.The arylation reaction has been extended to 5-ethylbarbituric acid and to barbituric acid itself, which affords the 5,5-diarylated derivatives in good yield.A study of the effect of some tertiary bases on the reaction of p-methoxyphenyllead triacetate with the 5-isopropyl derivative of Meldrum's acid has shown that replacement of pyridine by 2,2'-bipyridyl results in an increase in yield and reaction rate, while a further marked improvement occurs in the presence of 1,10-phenanthroline.