219144-67-9Relevant academic research and scientific papers
Design, synthesis and α-glucosidase inhibition study of novel embelin derivatives
Chen, Wenhua,Chen, Xiaole,Gao, Min,Hong, Weiqian David,Jian, Rongchao,Li, Yuling,Sheng, Zhaojun,Tang, Xiaowen,Wu, Panpan,Zhang, Kun,Zhao, Denggao,Zheng, Xi
, p. 565 - 573 (2020/02/15)
Embelin is a naturally occurring para-benzoquinone isolated from Embelia ribes (Burm. f.) of the Myrsinaceae family. It was first discovered to have potent inhibitory activity (IC50 = 4.2 μM) against α-glucosidase in this study. Then, four seri
Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes
Filosa, Rosanna,Peduto, Antonella,Schaible, Anja M.,Krauth, Verena,Weinigel, Christina,Barz, Dagmar,Petronzi, Carmen,Bruno, Ferdinando,Roviezzo, Fiorentina,Spaziano, Giuseppe,D'Agostino, Bruno,De Rosa, Mario,Werz, Oliver
supporting information, p. 132 - 139 (2015/04/14)
5-Lipoxygenase (5-LO) is a potential target for pharmacological intervention with various inflammatory and allergic diseases. Starting from the natural dual 5-LO/microsomal prostaglandin E2 synthase (mPGES)-1 inhibitor embelin (2,5-dihydroxy-3-
Design, synthesis, and SAR of embelin analogues as the inhibitors of PAI-1 (plasminogen activator inhibitor-1)
Chen, Fanglei,Zhang, Guiping,Hong, Zebin,Lin, Zhonghui,Lei, Min,Huang, Mingdong,Hu, Lihong
supporting information, p. 2379 - 2382 (2014/05/20)
The natural product embelin was found to have PAI-1 inhibitory activity with the IC50 value of 4.94 μM. Based on the structure of embelin, a series of analogues were designed, synthesized, and evaluated for their ability to inhibit PAI-1. The SAR study on these compounds disclosed that the inhibitory potency largely depended on the hydroxyl groups at C2 and C5, and the length of the alkyl chains at C3 and C6. Compound 11 displayed the best PAI-1 inhibitory potency with the IC50 value of 0.18 μM.
Phytotoxic activity of quinones and resorcinolic lipid derivatives
Mizuno, Cassia S.,Rimando, Agnes M.,Duke, Stephen O.
scheme or table, p. 4353 - 4355 (2011/08/05)
On the basis of the reported phytotoxic activity of sorgoleone and resorcinolic lipids identified from the root extracts of Sorghum bicolor, 8 resorcinolic lipid derivatives and 10 quinones with various side chain sizes were synthesized. The phytotoxicity of the compounds was tested against a monocot and a dicot species. The quinones were phytotoxic, whereas the resorcinolic lipids were not. Of the quinones, 2-hydroxy-5-methoxy-3- pentylcyclohexa-2,5-diene-1,4-dione, having a five-carbon side chain, showed phytotoxic activity similar to that of natural compound sorgoleone. This article not subject to U.S. Copyright. Published 2010 by the American Chemical Society.
Total synthesis of maesanin and analogues
Poigny, Stephane,Guyot, Michele,Samadi, Mohammad
, p. 14791 - 14802 (2007/10/03)
An efficient total synthesis of maesanin and related quinones is reported, through direct alkylation of 1,2,4,5-tetramethoxybenzene with alkylbromides, followed by oxidation with ceric ammonium nitrate (CAN) which provokes formation of the quinone and dep
