2441-46-5Relevant articles and documents
Verhoeven et al.
, p. 3395 (1969)
Design, synthesis and α-glucosidase inhibition study of novel embelin derivatives
Chen, Wenhua,Chen, Xiaole,Gao, Min,Hong, Weiqian David,Jian, Rongchao,Li, Yuling,Sheng, Zhaojun,Tang, Xiaowen,Wu, Panpan,Zhang, Kun,Zhao, Denggao,Zheng, Xi
, p. 565 - 573 (2020/02/15)
Embelin is a naturally occurring para-benzoquinone isolated from Embelia ribes (Burm. f.) of the Myrsinaceae family. It was first discovered to have potent inhibitory activity (IC50 = 4.2 μM) against α-glucosidase in this study. Then, four seri
Alpha-glucosidase inhibitor based on p-hydroxyquinone framework and preparation method and application of inhibitor
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Paragraph 0048-0052; 0070-0074; 0092-0096, (2019/07/16)
The invention discloses an alpha-glucosidase inhibitor based on a p-hydroxyquinone framework and a preparation method and application of inhibitor. The glucosidase inhibitor is obtained through six-step synthesis with a natural product framework p-hydroxyquinone as an initial raw material. The compound can effectively inhibit the activity of alpha-glucosidase, the aim of controlling excessively high blood glucose is achieved by delaying absorption of the intestinal tract to glucose, and the inhibitor is used for treating diabetes and obesity and has a heart blood vessel protection function.