21916-53-0Relevant academic research and scientific papers
Regioselective rhodium-catalyzed intermolecular [2+2+2] cycloaddition of alkynes and isocyanates to form pyridones
Oberg, Kevin M.,Lee, Ernest E.,Rovis, Tomislav
experimental part, p. 5056 - 5061 (2009/10/24)
A highly regioselective rhodium-catalyzed intermolecular [2+2+2] cycloaddition of terminal alkynes with a variety of isocyanates to provide 2- and 4-pyridones has been developed. This reaction proceeds in good to excellent yields and overcomes the problem of dimerization and trimerization through the use of phosphoramidite ligands. A CO migration in the metallacycle is proposed to account for the formation of 4-pyridone.
2- and 4-Pyridones by Oxidative Demethylation of 2- and 4-Methylpyridinium Cations
Katritzky, Alan R.,Patel, Ranjan C.,Shanta, Mohammed
, p. 1888 - 1889 (2007/10/02)
1-Substituted-2- and -4-methylpyridinium cations are converted by pentyl or ethyl nitrite and sodium methoxide into 1-substituted-2- and -4-pyridones respectively.
α-(4,6-Diphenyl-2-oxo-1-pyridyl)benzyl-lithiums and their Reactions with Electrophiles
Katritzky, Alan R.,Arrowsmith, John,Bahari, Zakaria bin,Jayaram, Chandra,Siddiqui, Tayyaba,Vassilatos, Socrates
, p. 2851 - 2855 (2007/10/02)
1-Benzyl-4,6-diphenyl-2-pyridone is lithiated by LiNPri2 at the methylene carbon to form a carbanion which reacts with various electrophiles to give the corresponding 1-(α-substituted-benzyl)-4,6-diphenyl-2-pyridones.Potassium dimsylate convert
