21917-99-7Relevant academic research and scientific papers
Fast and Efficient Continuous Flow Method for the Synthesis of Ynones and Pyrazoles
Kandasamy, Mohanraj,Ganesan, Balaji,Hung, Min-Yuan,Lin, Wei-Yu
supporting information, p. 3183 - 3189 (2019/05/28)
In this study, we developed a convenient and efficient two-step method for the synthesis of ynones in a flow reactor, through the generation of lithium acetylide and its subsequent reactions with acid chlorides. Using this approach, we obtained the ynones in moderate to good yields at room temperature. Moreover, we transformed the ynones into pyrazole derivatives through coupling with hydrazines. This transition metal-free process, mild reaction conditions, and broad functional group tolerance are all attractive features in comparison with conventional bench-top methods.
Visible-light promoted one-pot synthesis of pyrazoles from alkynes and hydrazines
Meng, Yunge,Zhang, Te,Gong, Xinchi,Zhang, Min,Zhu, Chunyin
supporting information, p. 171 - 174 (2018/12/11)
A visible-light promoted cascade of Glaser coupling/annulation has been developed for one-pot synthesis of polysubstituted pyrazoles from alkynes and hydrazines. The method features mild reaction conditions, readily availible starting materials and green
Method for preparing polysubstituted pyrazole through one-pot reaction of substituted alkyne and hydrazine or hydrazine substitute
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Paragraph 0016; 00017, (2019/02/04)
The invention belongs to the technical field of drug intermediate preparation and specifically relates to a method for preparing polysubstituted pyrazole through one-pot reaction of substituted alkyneand hydrazine or hydrazine substitute. The polysubstitu
Gold-catalyzed hydroamination of alkynes and allenes with parent hydrazine
Kinjo, Rei,Donnadieu, Bruno,Bertrand, Guy
supporting information; experimental part, p. 5560 - 5563 (2011/07/30)
A diverse array of nitrogen-containing compounds were formed by the addition of hydrazine to alkynes, diynes, enynes, and allenes in the presence of cationic gold(I) complexes with a cyclic (alkyl)(amino)carbene ligand (see scheme; the X-ray crystal structure of the gold-hydrazine complex is shown). This hydroamination is an ideal initial step for the preparation of acyclic and heterocyclic bulk chemicals. Dipp=2,6-diisopropylphenyl. Copyright
