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5',3'-bis-O-trityl-2'-fluoro-2'-deoxyuridine is a chemical compound that belongs to the class of nucleoside derivatives. It is a modified version of the naturally occurring nucleoside uridine, with a fluorine atom at the 2' position and trityl groups protecting the 5' and 3' hydroxyl groups. 5',3'-bis-O-trityl-2'-fluoro-2'-deoxyuridine is often used in organic synthesis and medicinal chemistry, particularly in the development of antiviral drugs targeting RNA viruses. The trityl groups serve to protect the sugar moiety during chemical reactions, allowing for selective modification of other functional groups in the molecule. The 2'-fluoro substitution can enhance the stability and binding affinity of the nucleoside to its target enzymes or receptors, making it a valuable intermediate in the synthesis of more complex bioactive molecules.

2192-61-2

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2192-61-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2192-61-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,9 and 2 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 2192-61:
(6*2)+(5*1)+(4*9)+(3*2)+(2*6)+(1*1)=72
72 % 10 = 2
So 2192-61-2 is a valid CAS Registry Number.

2192-61-2Downstream Products

2192-61-2Relevant academic research and scientific papers

Anti-flavivirus Activity of Different Tritylated Pyrimidine and Purine Nucleoside Analogues

McGuigan, Christopher,Serpi, Michaela,Slusarczyk, Magdalena,Ferrari, Valentina,Pertusati, Fabrizio,Meneghesso, Silvia,Derudas, Marco,Farleigh, Laura,Zanetta, Paola,Bugert, Joachim

, p. 227 - 235 (2016/07/07)

A series of tritylated and dimethoxytritylated analogues of selected pyrimidine and purine nucleosides were synthesized and evaluated for their in vitro inhibitory activity against two important members of the genus Flavivirus in the Flaviviridae family, the yellow fever (YFV) and dengue viruses (DENV). Among all compounds tested, the 5′-O-tritylated and the 5′-O-dimethoxytritylated 5-fluorouridine derivatives exerted potency against YFV. Interestingly in the series of purine analogues, the 5′O, N-bis-tritylated fludarabine derivative revealed strong inhibitory activity against DENV at μm concentrations, however significantly weaker potency against YFV.

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