16731-33-2

Upstream product

• 3736-77-4 2,2'-Anhydrouridine 
• 76-83-5 trityl chloride 
• 58-96-8 uridine 
• 22860-36-2 2,2'-anhydro-1-(3',5'-di-O-trityl-β-D-arabinofuranosyl)uracil 

Downstream Products

• 2192-61-2 5',3'-bis-O-trityl-2'-fluoro-2'-deoxyuridine 
• 56287-17-3 2'-deoxy-2'-fluorouridine 
• 127841-13-8 4-Amino-1-((2R,3S,4R,5R)-3,4-difluoro-5-trityloxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one 
• 127840-98-6 1-(2,3-dideoxy-2,3-difluoro-5-O-trityl-β-D-ribofuranosyl)uracil 
• 127841-02-5 3'-azido-2'-fluoro-5'-O-trityl-2',3'-dideoxyuridine 
• 127841-01-4 1-(2-deoxy-2-fluoro-3-O-mesyl-5-O-trityl-β-D-xylofuranosyl)uracyl 
• 127840-97-5 1-(2-deoxy-2-fluoro-5-O-trityl-β-D-xylofuranosyl)uracil 
• 2923-90-2 5'-O-trityl-2'-deoxy-2'-fluorouridine 

Relevant academic research and scientific papers

Simple and effective method for the synthesis of 3′,5′-substituted 1-β-D-arabinofuranosyluracil

3′,5′-Substituted arabinofuranosyluracil is a starting compound in 2′-modifications. A convenient and effective method is proposed for the synthesis of 1-(3′,5′-di-o-trityl-β-D-arabinofuranosyl)uracil by successive reactions of 2,2′-cyclization of uridine, 3′,5′-tritylation of the 2,2′-anhydrouridine, and hydrolytic cleavage of the 2,2′-anhydro bond. 1997 Plenum Publishing Corporation.

SYNTHESIS OF 2'-CHLORO-2',3'-DIDEOXY-2',3'-DIDEHYDRO NUCLEOSIDES

Treatment of O2,2'-anhydrouridine with triphenylmethyl chloride in pyridine at 80 deg C gives mainly the 2'-chlorinated nucleoside 3.Reaction of 2'-chloro-3'-O-trifluoromethanesulfonyl-5'-O-trityl-2'-deoxyuridine (4) with NaOH led exclusively t