21928-40-5

Basic information

• Product Name: Ethyl 4-(4-chloro-3-(trifluoromethyl)phenyl)-4-hydroxypiperidine-1-carboxylate
• Synonyms: ethyl 4-[4-chloro-3-(trifluoromethyl)phenyl]-4-hydroxypiperidine-1-carboxylate;4-[4-Chloro-3-(trifluoromethyl)phenyl]-4-hydroxy-1-piperidinecarboxylic acid ethyl ester;Einecs 244-664-1
• CAS NO: 21928-40-5
• Molecular Formula: C₁₅H₁₇ClF₃NO₃
• Molecular Weight: 351.75
• EINECS: 244-664-1
• Mol File: 21928-40-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 404.1 °C at 760 mmHg
• Flash Point: 198.2 °C
• Appearance: /
• Density: 1.37g/cm³
• Vapor Pressure: 2.95E-07mmHg at 25°C
• Refractive Index: 1.519
• CAS DataBase Reference: Ethyl 4-(4-chloro-3-(trifluoromethyl)phenyl)-4-hydroxypiperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 4-(4-chloro-3-(trifluoromethyl)phenyl)-4-hydroxypiperidine-1-carboxylate(21928-40-5)
• EPA Substance Registry System: Ethyl 4-(4-chloro-3-(trifluoromethyl)phenyl)-4-hydroxypiperidine-1-carboxylate(21928-40-5)

Safety Data

• Hazardous Substances Data: 21928-40-5(Hazardous Substances Data)

Usage

General Description

Ethyl 4-(4-chloro-3-(trifluoromethyl)phenyl)-4-hydroxypiperidine-1-carboxylate is a chemical compound with a complex molecular structure. It is a piperidine derivative with a chloro-substituted phenyl ring and a trifluoromethyl group, as well as an ethyl ester functional group. Ethyl 4-(4-chloro-3-(trifluoromethyl)phenyl)-4-hydroxypiperidine-1-carboxylate is used in pharmaceutical research and development as a building block for the synthesis of potential drug candidates. Its precise chemical structure makes it a valuable tool for investigating the biological activity and pharmacological properties of related compounds. Additionally, the presence of a hydroxyl group and carboxylate moiety suggests potential for modification and utilization in drug discovery and medicinal chemistry.

InChI:InChI=1/C15H17ClF3NO3/c1-2-23-13(21)20-7-5-14(22,6-8-20)10-3-4-12(16)11(9-10)15(17,18)19/h3-4,9,22H,2,5-8H2,1H3

Upstream product

• 445-01-2 5-bromo-2-chlorobenzotrifluoride 
• 106-93-4 ethylene dibromide 
• 29976-53-2 N-ethoxycarbonyl-4-piperidone 
• 21928-50-7 4-[4-chloro-3-trifluoromethylphenyl]-4-piperidinol 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 21928-50-7 4-[4-chloro-3-trifluoromethylphenyl]-4-piperidinol 
• 26864-56-2 penfluridol 
• 50830-38-1 1-[4,4-bis(4-fluorophenyl)butyryl]-4-(3-trifluoromethyl-4-chlorophenyl)-4-piperidinol 
• 863111-30-2 4-[4-chloro-3-(trifluoromethyl)phenyl]-4-methoxypiperidine 

Relevant articles and documents

Penfluridol preparation method

The invention discloses a penfluridol preparation method. The penfluridol preparation method includes the following steps of 1), subjecting succinic anhydride and fluorobenzene to Friedel-Crafts reaction prior to acid decomposition, and collecting a compound from the formula 2) as is shown in the description; 2), putting the compound in a solvent to collect a compound in formula 3) as is shown in the description in a solvent reduced through a reducing agent; 3), putting the compound into the fluorobenzene to perform the Friedel-Crafts reaction to collect a compound in the formula 4) as is shown in the description; subjecting the compound and ethyl chloroformate to action to generate a compound in formula 5) as is shown in the description; 5), subjecting the compound and a compound shown in formula (XVII) to reaction prior to hydrolyzation to collect a compound in formula 6) as is shown in the description; 6), performing reduction with the reducing agent prior to hydrolyzing a reduction product and then collecting penfluridol (I). The penfluridol preparation method is high in yield, low in cost, moderate in reaction condition, short in circuit, proper for industrial production, low in three wastes, easy to treat and suitable for industrial production.

Neurotropic and psychotropic agents. LXVII. 1 [4,4 bis(4 fluorophenyl)butyl] 4 hydroxy 4 (3 trifluoromethyl 4 chlorophenyl)piperidine and related compounds: new synthetic approaches

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