21932-49-0

Upstream product

• 106-47-8 4-chloro-aniline 
• 66-99-9 β-naphthaldehyde 
• 536-74-3 phenylacetylene 
• 54886-82-7 2'-acetonaphthone carbomethoxyhydrazone 
• 719-59-5 5-chloro-2-aminobenzophenone 

Relevant academic research and scientific papers

Efficient and environmentally-benign three-component synthesis of quinolines and bis-quinolines catalyzed by recyclable potassium dodecatungstocobaltate trihydrate under microwave irradiation

Microwave-assisted one-pot three-component reaction between aromatic amines, aromatic aldehydes and phenylacetylene is accomplished efficiently in the presence of catalytic amounts of potassium dodecatungstocobaltate trihydrate (K5CoW12O40?·3H2O) to afford the corresponding quinolines and bis-quinolines in excellent yields. Selective conversion of aromatic aldehyde and also arylacetylene to their corresponding quinolines in the presence of aliphatic aldehyde and alkylacetylene, respectively, can be considered as noteworthy advantages of this method and makes it a useful and attractive process for the synthesis of quinoline derivatives. The catalyst could be reused for several cycles without any significant loss of its catalytic activity.

The Preparation of Quinolines and Related Fused-Ring Heterocycles from the Dianions of Benzoylacetone, Certain Cyclic Ketone Oximes, or Certain Substituted Hydrazones

C(α),O-Dilithiooximes, C(α),N-dilithiobenzoylhydrazones, or C(α),N-dilithiocarboalkoxyhydrazones were prepared in an excess of lithium diisopropylamide (LDA) and condensed with 2-aminobenzophenones, or isatoic anhydrides to give intermediates that were treated with aqueous acid, which caused their hydrolysis, cyclodehydration and/or linear dehydration to give products which were substituted quinolines or related fused-ring heterocycles (e.g., cycloheptaquinolines).Dilithiobenzoylacetone was condensed with 2-aminobenzophenones, which was followed by acid cyclodehydration to substituted 2-phenacylquinolines.