219323-42-9Relevant academic research and scientific papers
AN ORGANOGELATOR COMPOUND
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Paragraph 00146-00148, (2017/03/23)
An organogelator compound is provided. The organogelator compound has Formula (I): wherein R1, R2, and R3 are independently selected from the group consisting of H, halogen, a substituted or unsubstituted C1-C20 alkyl, a substituted or unsubstituted C1-C20 alkoxy, a substituted or unsubstituted C2-C20 alkenyl, a substituted or unsubstituted C2-C20 alkynyl, a substituted or unsubstituted C3-C20 alicyclic group, a substituted or unsubstituted C5-C15 aryl, a substituted or unsubstituted C6-C30 alkyl-aryl, a substituted or unsubstituted C3-C20 heterocycle, a substituted or unsubstituted C4-C30 alkyl-heterocycle, a substituted or unsubstituted C5-C15 heteroaryl, -NRR', -NR, -OR, -SR, -CN, -NO2, -C(O)-R, -COOR, -NR'- C(O)-R, -C(O)-NRR', -C(NR)-R', -SO2-R, -(SO2)-OR, -C(S)-R, and -C(S)-NRR'; and R and R' are independently selected from the group consisting of H, halogen, a substituted or unsubstituted C1-C20 alkyl, a substituted or unsubstituted C1-C20 alkoxy, a substituted or unsubstituted C2-C20 alkenyl, a substituted or unsubstituted C2-C20 alkynyl, and a substituted or unsubstituted C5-C15 aryl. A method of gelating an oil and an organic solvent having a Polarity Index of less than 3 is also provided.
Ethyl 2-(tert-butoxycarbonyloxyimino)-2-cyanoacetate (Boc-Oxyma) as coupling reagent for racemization-free esterification, thioesterification, amidation and peptide synthesis
Thalluri, Kishore,Nadimpally, Krishna Chaitanya,Chakravarty, Maharishi Parasar,Paul, Ashim,Mandal, Bhubaneswar
supporting information, p. 448 - 462 (2013/05/09)
Here we report the synthesis and utility of ethyl 2-(tert- butoxycarbonyloxyimino)-2-cyanoacetate (Boc-Oxyma) as an efficient coupling reagent for racemization-free esterification, thioesterification, amidation reactions and peptide synthesis that uses equimolar amounts of acids and alcohols, thiols, amines or amino acids, respectively. Its application to solid phase as well as solution phase peptide synthesis is also demonstrated and a mechanistic investigation is discussed. Boc-Oxyma is similar to the well known coupling agent COMU {1-[1-cyano-2-ethoxy-2-oxoethylideneaminooxy)- dimethylaminomorpholino] uronium hexafluorophosphate} in terms of its high reactivity and mechanism of action. However, it is not only much easier to prepare, but also to recover and reuse, thereby generating far less chemical waste.
Catalyst and solvent-free amidation of inactive esters of N-protected amino acids
Nadimpally, Krishna Chaitanya,Thalluri, Kishore,Palakurthy, Nani Babu,Saha, Abhijit,Mandal, Bhubaneswar
supporting information; experimental part, p. 2579 - 2582 (2011/06/21)
A catalyst free procedure for the preparation of amides from inactive esters of N-protected amino acids and various amines is demonstrated under mild reaction conditions. Our effort to recover excess amine and generated alcohol is an approach towards environment friendly and cost effective synthesis under easy operational conditions.
