219325-26-5

Upstream product

• 1122-62-9 2-acetylpyridine 
• 24544-04-5 2,6-diisopropylbenzenamine 

Downstream Products

• 902171-71-5 [FeCl₂[(2,6-diisopropyl)(1-(pyridin-2-yl)ethylidene)amine]]2 
• 1101898-57-0 [iridium(I)(1-(2-pyridyl)-2-(2,6-diisopropylphenyl)-2-aza-ethane)(1,5-cyclooctadiene)]Cl 
• 1031217-39-6 (C₅H₄NC(CH₃)2N(2,6-diisopropylphenyl))AlMe₂ 
• 1161853-83-3 [2-[1-(2,6-diisopropylphenylimino)ethyl]pyridyl]palladiumdibromide 
• 1204519-94-7 2,6-diisopropyl-N-[1-(pyridin-2-yl)ethyl]aniline 
• 502640-81-5 [(2,6-(i-propyl)2)C₆H₃NC(methyl)(2-pyridyl)]Rh(CO)(methyl)I₂ 
• 502640-85-9 [(2,6-(i-propyl)2)C₆H₃NC(methyl)(2-pyridyl)]Rh(CO)(C(O)CH₃)I₂ 
• 502640-75-7 [(2,6-(i-propyl)2)C₆H₃NC(methyl)(2-pyridyl)]Rh(CO)I*dichloromethane 
• 724425-50-7 K[(2,6-iPr₂C₆H₃)N-C(C₅H₄N)(=CH₂)] 

Relevant academic research and scientific papers

(Iminopyridine)Pd (II) complexes as versatile catalysts for copolymerization and terpolymerization of vinyl arene, ethylene, and carbon monoxide

Palladium catalysts modified with iminopyridine ligands were employed for ethylene/CO and styrene/CO copolymerization and ethylene/styrene/CO terpolymerization. Our studies revealed that the steric and electronic effects of the catalysts play key, yet dis

Synthesis and structural elucidation of (pyridyl)imine Fe(II) complexes and their applications as catalysts in transfer hydrogenation of ketones

Reactions of (pyridyl)imine ligands: 2,6-diisopropyl-N-[(pyridine-2-yl)methylene]aniline (L1), 2,6-diisopropyl-N-[(pyridine-2-yl)ethylidene]aniline (L2), 2,6-dimethyl-N-[(pyridine-2-yl)methylene]aniline (L3), 2,6-dimethyl-N-[(pyridine-2-yl)ethylidene]aniline (L4) and N-[(pyridine-2-yl)methylene]aniline (L5) with FeCl2 salt afforded the corresponding paramagnetic Fe(II) complexes [Fe(L1)2Cl][FeCl4] (Fe1), [Fe(L2)2Cl][FeCl4] (Fe2), [Fe(L3)2Cl][FeCl4] (Fe3), [Fe(L4)2Cl][FeCl4], (Fe4), [Fe(L5)2Cl2] (Fe5) in good yields. On the other hand, reactions of L1 with FeCl2 in the presence of NaPF6 afforded complex [Fe(L1)2Cl][PF6] (Fe6) in moderate yields. Molecular structures of complexes Fe1 and Fe2 reveal the formation of cationic species containing two N^N bidentate ligands and one chlorido co-ligand to give five-coordinate geometry with [FeCl4]? as counter-anion. On the other hand, complex Fe5, is an octahedral neutral species containing two bidentate L5 and two chlorido ligands. All the complexes (Fe1–Fe6) formed active catalysts in the transfer hydrogenation of ketones affording average yields of about 85%. The ligand architecture, reaction conditions and nature of substrate influenced the catalytic activities of the complexes. Mercury and subs-stoichiometric poisoning tests pointed to the existence of both Fe(0) nanoparticles and homogeneous Fe(II) species as the active intermediates.

PROCESS FOR PREPARING CONJUGATED DIENE (CO)POLYMERS IN THE PRESENCE OF A CATALYTIC SYSTEM COMPRISING A PYRIDYL IRON (III) COMPLEX

A process for preparing conjugated diene (co)polymers comprising polymerizing at least one conjugated diene in the presence of a catalytic system comprising: (a) at least one pyridyl iron (III) complex having general formula (I) or (II): wherein: —R1, R2, R3 and R4, identical or different, represent a hydrogen atom; or are selected from linear or branched, optionally halogenated C1-C20, preferably C1-C15, alkyl groups, optionally substituted cycloalkyl groups, optionally substituted aryl groups; —R5 represents a hydrogen atom, or is selected from linear or branched, optionally halogenated C1-C20, preferably C1-C15, alkyl groups, optionally substituted cycloalkyl groups, optionally substituted aryl groups; —X, identical or different, represent a halogen atom such as, for example, chlorine, bromine, iodine; or are selected from linear or branched C1-C20, preferably C1-C15, alkyl groups, —OCOR6 groups or —OR6 groups wherein R6 is selected from linear or branched C1-C20, preferably C1-C15, alkyl groups. —n is 3; (b) at least one co-catalyst selected from organo-aluminum derivatives, preferably from: (b1) aluminum compounds having general formula (III): Al(R7)(R8)(R9) (IIl) wherein R7 represents a hydrogen atom, or is selected from linear or branched C1-C20 alkyl groups, cycloalkyl groups, aryl groups, alkylaryl groups, arylalkyl groups, alkoxy groups; R8 and R9, identical or different, are selected from linear or branched C1-C20 alkyl groups, cycloalkyl groups, aryl groups, alkylaryl groups, arylalkyl groups; (b2) aluminoxanes having general formula (IV): (R10)2—Al—O—[-AI(R11)—O-]m-AI-(R12)2 (IV), wherein R10, R11 and R12, identical or different, represent a hydrogen atom, or a halogen atom such as chlorine, bromine, iodine, fluorine; or are selected from linear or branched C1-C20 alkyl groups, cycloalkyl groups, aryl groups, said groups being optionally substituted with one or more silicon or germanium atoms; and m is an integer ranging from 0 to 1000; (b3) partially hydrolyzed organo-aluminum derivatives; (b4) haloaluminum alkyls having general formula (V) or (VI): AI(R13)p(X′)3-p (V) AI2(R13)q(X′)3-q (VI) wherein p is 1 or 2; q is an integer ranging from 1 to 5; R13, identical or different, are selected from linear or branched C1-C20 alkyl groups; X′ represents a chlorine or bromine atom, preferably chlorine; provided that said co-catalyst (b) is not selected from organo-boron derivatives.

Highly active iminopyridyl iron-based catalysts for the polymerization of isoprene

A series of iminopyridyl-based ligands, 6-[(Ar)N=C(R)]-2-C6H5N [(Ar = 2,6-Me2-C6H3, R = Me (L1); Ar = 2,6-iPr2-C6H3, R = Me (L2); Ar = 2,6-Me2-C6H3, R = H (

Lysosome-Targeted Chemotherapeutics: Half-Sandwich Ruthenium(II) Complexes That Are Selectively Toxic to Cancer Cells

Poor selectivity between cancer cells and normal cells is one of the major limitations of cancer chemotherapy. Lysosome-targeted ruthenium-based complexes target tumor cells selectively, only displaying rather weak cytotoxicity or inactivity toward normal cells. Confocal microscopy was employed for the first time to determine the cellular localization of the half-sandwich Ru complex.

Novel half-sandwich iridium(iii) imino-pyridyl complexes showing remarkable: In vitro anticancer activity

Seven novel half-sandwich IrIII cyclopentadienyl complexes, [(η5-Cpx)Ir(N^N)Cl]PF6, have been prepared and characterized, where Cpx is Cp? or the biphenyl derivative Cpxbiph (C5Me4C6H4C6H5), and the N^N-chelating ligands are imino-pyridyl Schiff-bases. The X-ray crystal structures of complexes 2A, 2B, and 3A have been determined. Excitingly, most of the complexes show potent antiproliferative activity towards A549 and HeLa cancer cells, except for Cp? complex 1A towards HeLa cells. Cpxbiph complex 2B displayed the highest potency, about 19 and 6 times more active than the clinically used drug cisplatin toward A549 and HeLa cells, respectively. These complexes undergo hydrolysis, and the kinetics data have been calculated. DNA binding has been studied by interaction with nucleobases 9-ethylguanine and 9-methyladenine, cleavage of plasmid DNA, and interaction with ctDNA. Interaction with DNA does not appear to be the major mechanism of action. Protein binding (bovine serum albumin, BSA) has been established by UV-Vis, fluorescence and synchronous spectroscopic studies. The stability of complex 2B in the presence of GSH was evaluated. The complexes catalytically convert coenzyme NADH to NAD+via hydride transfer. Cpxbiph complexes 2B and 4B induce cell apoptosis and arrest cell cycles at the S and G2/M phases towards A549 cancer cells and increase the reactive oxygen species dramatically, which appear to contribute to the remarkable anticancer activity.

Half-sandwich ruthenium(ii) complexes containing N^N-chelated imino-pyridyl ligands that are selectively toxic to cancer cells

Chemotherapy is limited by its poor selectivity towards cancer cells over normal cells. Herein, we designed half-sandwich ruthenium imino-pyridyl complexes [(η6-bz)Ru(N^N)Cl]PF6 to achieve selective cytotoxicity to cancer cells. This kind of ruthenium complex has unique characteristics and is worthy of further exploration in the design of new anticancer drugs.

NITROGEN TITANIUM COMPLEX, CATALYTIC SYSTEM COMPRISING SAID NITROGEN TITANIUM COMPLEX AND PROCESS FOR THE (CO)POLYMERIZATION OF CONJUGATED DIENES

Nitrogen titanium complex having general formula (I) or (II), wherein: - R1 represents a hydrogen atom; or is selected from linear or branched C1-C20 alkyl groups, preferably C1-C15, optionally halogenated, cycloalkyl groups optionally substituted, aryl groups optionally substituted; - R2, R3, R4 and R5, identical or different, represent a hydrogen atom; or are selected from linear or branched C1-C20 alkyl groups, preferably C1-C15, optionally halogenated, cycloalkyl groups optionally substituted, aryl groups optionally substituted, nitro groups, hydroxyl groups, amino groups; - Y represents a NH-R6 group wherein R6 represents a hydrogen atom, or is selected from linear or branched C1-C20 alkyl groups, preferably C1-C15, optionally halogenated, cycloalkyl groups optionally substituted, aryl groups optionally substituted; or a N-R7 group wherein R7 is selected from linear or branched C1-C20 alkyl groups, preferably C1-C15, optionally halogenated, cycloalkyl groups optionally substituted, aryl groups optionally substituted; - X1, X 2, X 3 and X 4, identical or different, represent a halogen atom, such as, for example, chlorine, bromine, iodine, preferably chlorine; or are selected from linear or branched C1 -C20 alkyl groups, preferably C1-C15, -OCOR8 or -OR8 groups wherein R8 is selected from linear or branched C1-C20 alkyl groups, preferably C1-C15; or one of X1, X2 and X3 is selected from ethers, such as,for example, diethylether, tetrahydrofuran (THF), dimethoxyethane, preferably tetrahydrofuran (THF); - n is 1 in the case wherein Y represents a NH-R6 group wherein R6 has the same meanings reported above; or is 0 in the case wherein Y represents a N-R7 group wherein R7 has the same meanings reported above, or in the case wherein one of X1, X2 and X3 is selected from ethers; - R'1, R' 2, R'3, R'4, R'5, R'6 and R'7, identical or different, represent a hydrogen atom; or are selected from linear or branched C1-C20 alkyl groups, preferably C1-C15, optionally halogenated, cycloalkyl groups optionally substituted, aryl groups optionally substituted; - X'1 and X'2, identical or different, represent a halogen atom such as, for example, chlorine, bromine, iodine, preferably chlorine; or are selected from linear or branched C1-C20 alkyl groups, preferably C1-C15, -OCOR'8 groups or -OR'8 groups wherein R' 8 is selected from linear or branched C1-C20 alkyl groups, preferably C1-C15; - Y' is selected from ethers such as, for example,diethylether, tetrahydrofuran (THF), dimethoxyethane, preferably is tetrahydrofuran (THF); or Y' represents a group having general formula (III), wherein R'1, R' 2, R'3, R'4, R'5, R'6 and R'7, have the same meanings as reported above; - m is 0 or 1. Said nitrogen titanium complex having general formula (I) or (II) can be advantageously used in a catalytic system for the (co)polymerization of conjugated dienes.

VANADIUM PYRIDINE-IMINE COMPLEX, CATALYTIC SYSTEM COMPRISING SAID VANADIUM PYRIDINE-IMMINE COMPLEX AND A (CO) POLYMERIZATION PROCESS OF CONJUGATED DIENES

Vanadium pyridine-imine complex having general formula (I), wherein : - R1, R2, R3, R4, R5 and R6, equal to or different from each other, represent a hydrogen atom; or are selected from lin

First-Row Transition Metal and Lithium Pyridine-ene-amide Complexes Exhibiting N- and C-Isomers and Ligand-Based Activation of Benzylic C-H Bonds

Ene-amines Z-3-(2-pyridyl)-1-aza(2,6-iPr2-Ph)propene, (pynac)H, and 2-(2-pyridyl)-1-aza(2,6-R,R′-Ph)propene, (pyEA-ArRR′)H, were synthesized by condensation procedures; corresponding lithium or potassium ene-amides were prepared via standard deprotonation protocols. Addition of 2 equiv of (pynac)H to {(Me3Si)2N}2Fe(THF) or 2 Li(pynac) to FeBr2(THF)2 afforded (pynac)2Fe (1), while treatment of CrCl2(THF)2, MnCl2, FeBr2(THF)2, and CoCl2py4 with 2 equiv of (pyEA-AriPr2)K afforded pseudotetrahedral (pyEA-AriPr2)2M (2-M, M = Cr, Mn, Fe) and (pyEA-AriPr2)2Co-py (2-Co-py). Diamagnetic (κ-C,N-pyEA-AriPr2)3Co (3) was prepared in low yield (～7%) from CoCl2, and its Co-C(sp3) linkages are unusually low in field strength. Reactivity studies yielded little clean reactivity, but thermolysis of 2-Co-py afforded the bis-indolamide derivative {κ-N,N-N(C6H3(2-iPr)CMe2C(Me)(2-py)}2Co (5-Co), and related thermolyses of 2-M (M = Cr, Mn, Fe), conducted on NMR tube scales, generated related 5-M (M = Cr, Mn, Fe) at roughly the same rates. This observation prompted thermolyses of (pyEA-ArRR′)Li, which rearrange to their corresponding indolamides in >90% yields. Rate studies, accompanied by KIE and EIE observations, revealed that an initial hydrogen transfer is reversible and is likely to correspond to an anionic rearrangement, whereas C-C bond formation is rate-determining, as suggested by accompanying calculations. X-ray structure determinations of 1, 2-Fe, 2-Co-py, 3, and 5-Co were conducted.