21943-76-0Relevant academic research and scientific papers
Palladium-catalyzed decarboxylative intramolecular aziridination from 4h-isoxazol-5-ones leading to 1-azabicyclo[3.1.0]hex-2-enes
Okamoto, Kazuhiro,Oda, Tomohiro,Kohigashi, Sho,Ohe, Kouichi
supporting information; experimental part, p. 11470 - 11473 (2012/01/11)
A decarboxylative intramolecular aziridination reaction of alkene-tethered 4H-isoxazol-5-ones with a palladium/phosphine catalyst gave 1-azabicyclo[3.1.0] hex-2-enes in moderate to high yields (see scheme; dba=dibenzylideneacetone). The resulting N-fused bicyclic aziridines readily reacted with various reagents to afford ring-opening pyrroline derivatives.
