219489-75-5Relevant academic research and scientific papers
Antithrombotic agents
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, (2008/06/13)
This application relates to a compound of formula (I), a pharmaceutically acceptable salt of the compound, or a prodrug thereof, as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
N2-aroylanthranilamide inhibitors of human factor Xa
Yee, Ying K.,Tebbe, Anne Louise,Linebarger, Jared H.,Beight, Douglas W.,Craft, Trelia J.,Gifford-Moore, Donetta,Goodson Jr., Theodore,Herron, David K.,Klimkowski, Valentine J.,Kyle, Jeffrey A.,Sawyer, J. Scott,Smith, Gerald F.,Tinsley, Jennifer M.,Towner, Richard D.,Weir, Leonard,Wiley, Michael R.
, p. 873 - 882 (2007/10/03)
Reversal of the A-ring amide link in 1,2-dibenzamidobenzene 1 (fXa K(ass) = 0.81 x 106 L/mol) led to a series of human factor Xa (hfXa) inhibitors based on N2-aroylanthranilamide 4. Expansion of the SAR around 4 showed that only smal
