20878-54-0

Basic information

• Product Name: 2-AMINO-N-(4-METHOXY-PHENYL)-BENZAMIDE
• Synonyms: 4'-Methoxyanthranilanilide
• CAS NO: 20878-54-0
• Molecular Formula: C₁₄H₁₄N₂O₂
• Molecular Weight: 242.28
• Mol File: 20878-54-0.mol
• Article Data: 47

Chemical Properties

• Boiling Point: 349°Cat760mmHg
• Flash Point: 164.9°C
• Appearance: /
• Density: 1.245g/cm³
• Vapor Pressure: 4.83E-05mmHg at 25°C
• Refractive Index: 1.658
• CAS DataBase Reference: 2-AMINO-N-(4-METHOXY-PHENYL)-BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-N-(4-METHOXY-PHENYL)-BENZAMIDE(20878-54-0)
• EPA Substance Registry System: 2-AMINO-N-(4-METHOXY-PHENYL)-BENZAMIDE(20878-54-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 20878-54-0(Hazardous Substances Data)

Usage

General Description

2-AMINO-N-(4-METHOXY-PHENYL)-BENZAMIDE is a chemical compound with the molecular formula C14H14N2O2. It is a benzamide derivative and contains an amino group and a methoxyphenyl group. 2-AMINO-N-(4-METHOXY-PHENYL)-BENZAMIDE may have various pharmaceutical and biological applications due to its structural features and functional groups. It could potentially be used as a building block in the synthesis of other organic compounds, or it may exhibit specific pharmacological properties that make it suitable for drug development. Further research and testing would be necessary to determine its specific uses and potential benefits in various fields of chemistry and medicine.

InChI:InChI=1/C14H14N2O2/c1-18-11-8-6-10(7-9-11)16-14(17)12-4-2-3-5-13(12)15/h2-9H,15H2,1H3,(H,16,17)

Upstream product

• 22979-83-5 2-nitro-N-(4-methoxyphenyl)benzamide 
• 934248-68-7 C₁₄H₁₅N₂O₂P 
• 118-92-3 anthranilic acid 
• 271-58-9 anthranil 
• 104-94-9 4-methoxy-aniline 
• 552-16-9 ortho-nitrobenzoic acid 
• 21563-73-5 2-aminobenzoyl chloride 
• 118-48-9 isatoic anhydride 
• 91-56-5 indole-2,3-dione 
• 610-14-0 2-nitrobenzyl chloride 
• 134-20-3 2-carbomethoxyaniline 

Downstream Products

• 92944-78-0 N-(4'-Nitrobenzyl)anthranilic acid 4-anisidide 
• 94565-40-9 2-(3,4-Dimethoxy-phenyl)-3-(4-methoxy-phenyl)-2,3-dihydro-1H-quinazolin-4-one 
• 94565-45-4 3-(4-Methoxy-phenyl)-2-((E)-styryl)-2,3-dihydro-1H-quinazolin-4-one 
• 22378-45-6 3-(4-Methoxy-phenyl)-3H-quinazolin-4-one 
• 133040-85-4 2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(4-methoxy-phenyl)-3H-quinazolin-4-one 
• 127662-31-1 3-(4-methoxy-phenyl)-1,2,3,4-tetrahydro-quinazoline 
• 361186-79-0 2-phenyl-3-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one 
• 23098-28-4 4-(4-methoxyphenyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione 
• 312311-49-2 2-{4-methoxy-3-[(4-nitro-1H-pyrazol-1-yl)methyl]phenyl}-3-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one 
• 312626-83-8 C₂₈H₂₃N₃O₂ 
• 30838-15-4 N-[2-(4-Methoxy-phenylcarbamoyl)-phenyl]-oxalamic acid ethyl ester 
• 489446-50-6 2-(3-methoxy-benzylamino)-N-(4-methoxy-phenyl)-benzamide 

Relevant articles and documents

One-pot synthesis ofN-substituted benzannulated triazolesviastable arene diazonium salts

A mild and effective one-pot synthesis of 1,2,3-benzotriazin-4(3H)-ones and benzothiatriazine-1,1(2H)-dioxide analogues has been developed. The method involves the diazotisation and subsequent cyclisation of 2-aminobenzamides and 2-aminobenzenesulfonamidesviastable diazonium salts, prepared using a polymer-supported nitrite reagent andp-tosic acid. The transformation was compatible with a wide range of aryl functional groups and amide/sulfonamide-substituents and was used for the synthesis of pharmaceutically important targets. The synthetic utility of the one-pot diazotisaton-cyclisation process was further demonstrated with the preparation of an α-amino acid containing 1,2,3-benzotriazin-4(3H)-one.

Efficient synthesis of 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives catalyzed by functionalized nanoporous silica

An efficient and facile method has been developed for the synthesis of various 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives, via a three-component reaction of 2-amino-N-(R)-benzamide derivatives with 2-formylbenzoic acid using sulfonic acid functionalized nanoporous silica as an efficient catalyst in ethanol under reflux. High yield of the desired products, reusability of the catalyst, and effortless workup step without using chromatography are the advantages of this method. Graphic abstract: [Figure not available: see fulltext.]

Electrochemical utilization of methanol and methanol-d4 as a C1 source to access (deuterated) 2,3-dihydroquinazolin-4(1H)-one

Herein, an electrocatalytic protocol for the synthesis of 2,3-dihydroquinazolin-4(1H)-one has been disclosed. Methanol is activated and utilized as the C1 source to cyclize with 2-aminobenzamides. This cyclization reaction proceeds conveniently (room temperature and air atmosphere) without any homogeneous metal catalysts, external oxidants, or bases. A wide variety of N,N-disubstituted 2,3-dihydroquinazolin-4(1H)-ones are obtained via this approach. Moreover, when methanol-d4 is used, a deuterated methylene motif is incorporated into the N-heterocycles, providing an efficient approach to the deuterated N-heterocycles.