219523-50-9Relevant articles and documents
Synthesis of C-ring aromatic taxoids and evaluation of their multi-drug resistance reversing activity
Morihira, Koichiro,Nishimori, Toshiyuki,Kusama, Hiroyuki,Horiguchi, Yoshiaki,Kuwajima, Isao,Tsuruo, Takashi
, p. 2973 - 2976 (2007/10/03)
The C-aromatic taxoids were synthesized to develop effective inhibitors against drug efflux mediated by p-glycoproteins. Among those tested using multi-drug resistant tumor cells (2780AD), the benzoate 11 exhibited significant activity as potent as verapa