219538-19-9Relevant academic research and scientific papers
Synthesis of new 2,5-disubstituted-1,3,4-thiadiazoles and preliminary evaluation of anticonvulsant and antimicrobial activities
Dogan, Hatice N,Duran, Arzu,Rollas, Sevim,Sener, G?ksel,Uysal, Meral K,Gülen, Dumrul
, p. 2893 - 2898 (2007/10/03)
Two new series of 2,5-disubstituted-1,3,4-thiadiazoles were synthesized for their possible anticonvulsant, antibacterial and antifungal activities. The degree of protection afforded by these compounds at a dose of 100 mg/kg ip against pentylenetetrazole-induced convulsions in mice ranged from 0 to 90%. Among these compounds, 2a (90%) and 2g (70%) showed maximum protection. Antimicrobial tests showed that the MIC value of 3j against Pseudomanas aeruginosa was equal to that of penicillin.
Synthesis, structure elucidation and antimicrobial activity of some 3- hydroxy-2-naphthoic acid hydrazide derivatives
Dogan,Rollas,Erdeniz
, p. 462 - 467 (2007/10/03)
In this study, some 1,4-disubstituted thiosemicarbazide, 1,2,4-triazole and 1,3,4-thiadiazole type novel compounds derived from 3-hydroxy-2-naphthoic acid hydrazide were synthesized to screen for their antimicrobial activity. The structures of these substances were elucidated using elemental analysis and UV, 1H NMR, and mass spectral methods. All of these compounds were tested in vitro for their antibacterial and antifungal activity.
