21955-71-5

Upstream product

• 3695-29-2 5-iodo-2-pentanone 
• 603-35-0 triphenylphosphine 
• 90397-87-8 rac-5-iodopentan-2-ol 
• 5891-21-4 5-chloro-2-pentanone 

Downstream Products

• 1426395-31-4 Br^(1-)*C₃₁H₄₄NO₃P₂⁽¹⁺⁾ 
• 1426395-30-3 Br^(1-)*C₂₇H₃₆NO₃P₂⁽¹⁺⁾ 
• 87109-17-9 1-diphenylphosphinoyl-4-(2-methyl-[1,3]dioxolan-2-yl)-propane 
• 851779-77-6 1-[(1R,4S)-4-(4,4-Dimethoxy-1-methylene-butyl)-2,2-dimethyl-cyclobutyl]-4-(diphenyl-phosphinoyl)-3-methyl-6-(2-methyl-[1,3]dioxolan-2-yl)-hexan-3-ol 
• 21955-58-8 (3-(2-methyl-1,3-dioxolan-2-yl)propyl)triphenylphosphonium iodide 

Relevant academic research and scientific papers

ENZYME-MEDIATED PROCESS FOR MAKING AMBERKETAL AND AMBERKETAL HOMOLOGUES

An enzyme-mediated method for the production of Amberketal and Amberketal homologues, the products of said method, and uses of said products.

Synthesis and biological characterization of new aminophosphonates for mitochondrial pH determination by 31P NMR spectroscopy

A series of mitochondria targeted α-aminophosphonates combining a diethoxyphosphoryl group and an alkyl chain-connected triphenylphosphonium bromide tail were designed and synthesized, and their pH-sensitive 31P NMR properties and biological activities in vitro and in vivo were evaluated. The results showed a number of these mito-aminophosphonates exhibiting pKa values fitting the mitochondrial pH range, short relaxation, and chemical shift parameters compatible with sensitive 31P NMR detection, and low cytotoxicity on green algae and murine fibroblasts cell cultures. Of these, two selected compounds demonstrated to distribute at NMR detectable levels within the cytosolic and mitochondrial sites following their perfusion to isolated rat livers, with no detrimental effects on cell energetics and aerobic respiration. This study provided a new molecular scaffold for further development of in situ spectroscopic real-time monitoring of mitochondrion/cytosol pH gradients.

Synthesis of a caryophyllene isoprenologue, a potential diterpene natural product

(-)-β-Caryophyllene has been converted into three stereoisomers of a new bicyclic compound that is structurally related to the known macrocyclic diterpene, flexibilene, in the same way β-caryophyllene is related to humulene. Key steps are selective cleava

Synthesis of cyclic ethers from 3- and 4-hydroxyalkylphosphonium salts

The reaction of 6-methylene-1,3-dioxepanes derived from 3-hydroxyalkyltriphenylphosphonium salts and paraformaldehyde with trimethylsilyl trifluoromethanesulfonate in the presence of N,N- diisopropylethylamine yielded novel 4-formyltetrahydropyrans. 3-Met