219556-75-9

Upstream product

• 219556-74-8 5-iodo-5'-chloro-2',5'-dideoxyuridine 
• 219556-73-7 2-(1-{(2R,4S,5S)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-chloromethyl-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-ylamino)-N-prop-2-ynyl-acetamide 
• 951-78-0 2'-deoxyuridine 
• 219556-72-6 (1-{(2R,4S,5S)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-chloromethyl-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-ylamino)-acetic acid methyl ester 
• 219556-71-5 1-{(2R,4S,5S)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-chloromethyl-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione 
• 69260-67-9 5'-chloro-2',5'-dideoxyuridine 
• 54-42-2 5-Iodo-2'-deoxyuridine 

Relevant academic research and scientific papers

Modified oligonucleotides with a 5'-5' interbase semi-rigid junction for alternate strand triplex formation

Solid-phase synthesis of 5'-5'-linked oligonucleotides with opposite polarities tethered via nucleic bases has been performed using a modified dinucleoside bearing an H-phosphonate group at the 3'-position of one nucleoside and a dimethoxytrityl group at the 3'-position of the second nucleoside. This system is aimed at forming a base tetrad at the junction in order to provide better stabilization. The linker used between the two 5'- terminal bases in the same plane involves a triple bond in order to rigidify the junction. The two oligonucleotide chains are either made of natural nucleosides or one of them is built with N3'→P5' phosphoramidates.