219561-18-9Relevant academic research and scientific papers
Structural determinants of substrates and inhibitors: Probing glutamate transporters with 2,4-methanopyrrolidine-2,4-dicarboxylate
Esslinger, C. Sean,Koch, Hans P.,Kavanaugh, Michael P.,Philips, Dean P.,Chamberlin, A. Richard,Thompson, Charles M.,Bridges, Richard J.
, p. 3101 - 3106 (1998)
Using an intramolecular [2+2] photocyclization, 2,4-methanopyrrolidine- 2,4-dicarboxylate was prepared as a conformationally locked analogue of glutamate. This compound, in combination with two other pyrrolidine dicarboxylates, has been used to define the structural elements that differentiate substrate and nonsubstrate inhibitors of a high-affinity, sodium-dependent glutamate transporter.
