Bioorganic and Medicinal Chemistry Letters p. 3101 - 3106 (1998)
Update date:2022-08-05
Topics:
Esslinger, C. Sean
Koch, Hans P.
Kavanaugh, Michael P.
Philips, Dean P.
Chamberlin, A. Richard
Thompson, Charles M.
Bridges, Richard J.
Using an intramolecular [2+2] photocyclization, 2,4-methanopyrrolidine- 2,4-dicarboxylate was prepared as a conformationally locked analogue of glutamate. This compound, in combination with two other pyrrolidine dicarboxylates, has been used to define the structural elements that differentiate substrate and nonsubstrate inhibitors of a high-affinity, sodium-dependent glutamate transporter.
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Doi:10.1002/anie.199304231
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(1998)
