219565-74-9

Upstream product

• 35354-74-6 Honokiol 
• 329717-61-5 3-allyl-2'-methoxy-5'-propyl-biphenyl-4-ol 
• 1355484-75-1 C₁₆H₁₈O₂ 
• 140-67-0 Estragole 
• 672922-57-5 3-bromo-4-methoxymethoxybenzoic acid methyl ester 
• 711012-12-3 5-bromo-2-methoxymethoxy-benzoic acid methyl ester 
• 162269-91-2 (3-bromo-4-methoxymethoxy-phenyl)-methanol 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 4068-76-2 5-bromo-2-hydroxy-benzoic acid methyl ester 
• 29415-97-2 methyl 3-bromo-4-hydroxybenzoate 
• 89-55-4 5-bromosalicyclic acid 
• 711012-15-6 [5'-(tert-butyl-dimethyl-silanyloxymethyl)-4,2'-bis-methoxymethoxy-biphenyl-3-yl]-methanol 
• 711012-09-8 5'-(tert-butyl-dimethyl-silanyloxymethyl)-4,2'-bis-methoxymethoxy-biphenyl-3-carboxylic acid methyl ester 
• 711012-14-5 5,3'-diallyl-2,4'-bis-methoxymethoxy-biphenyl 

Relevant academic research and scientific papers

METHOD OF PRODUCING BIPHENOLIC COMPOUND, NOVEL BIPHENYL COMPOUND AND SYNTHESIS METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR TREATING PARKINSON'S DISEASE

A method of producing honokiol and analogues thereof, and novel intermediates prepared by virtue thereof are disclosed herein. A pharmaceutical composition for treating Parkinson's disease, which contains honokiol and/or the analogues thereof, is also disclosed herein.

An expedient synthesis of honokiol and its analogues as potential neuropreventive agents

An efficient synthesis of honokiol with Suzuki-Miyaura cross coupling obtained an overall yield of 45%. The proposed approach successfully synthesized several structurally similar alkyl, alkenyl and alkynyl analogues, seven of which showed potential neuropreventive activity against MPP+-induced and CHP/TBHP oxidative stress induced neuroblastoma cell death.

Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan

Honokiol, a biphenyl-type neolignan, which shows the remarkable neurotrophic effect in primary cultured rat cortical neurons, has been effectively synthesized in 21% yield over 14 steps starting from 5-bromosalicylic acid and p-hydroxybenzoic acid by utilizing Pd-catalyzed Suzuki-Miyaura coupling reaction as a key step. Additionally, the structure-activity relationship between neurite outgrowth-promoting activity and its O-methylated and/or its hydrogenated analogues was examined in the primary cultures of fetal rat cortical neurons, suggesting that 5-allyl and 4′-hydroxyl groups are essential for affecting the neurotrophic activity of honokiol.