711012-11-2

Upstream product

• 29415-97-2 methyl 3-bromo-4-hydroxybenzoate 
• 2973-78-6 3-bromo-4-hydroxybenzylaldehyde 
• 123-08-0 4-hydroxy-benzaldehyde 
• 162269-90-1 3-bromo-4-(methoxymethoxy)benzaldehyde 
• 672922-57-5 3-bromo-4-methoxymethoxybenzoic acid methyl ester 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 162269-91-2 (3-bromo-4-methoxymethoxy-phenyl)-methanol 

Downstream Products

• 1065546-02-2 bipinnatone A 
• 1065546-06-6 bipinnatone B 
• 1333078-54-8 C₂₄H₃₆O₃ 
• 1333078-61-7 C₁₉H₂₈O₃ 
• 1178514-07-2 (2E,6E)-4-methoxymethoxy-3-(3,7,11-trimethyldodeca-2,6,10-trienyl)benzaldehyde 
• 1178514-06-1 (2E)-3-(3,7-dimethyl-octa-2,6-dienyl)-4-methoxymethoxy-benzaldehyde 
• 1333078-56-0 C₃₈H₅₄O₉ 
• 1333078-63-9 C₃₃H₄₆O₉ 
• 1333078-53-7 C₃₀H₅₀O₃Si 
• 1333078-60-6 C₂₅H₄₂O₃Si 
• 219565-74-9 3'-(2-propenyl)-5-propyl-(1,1'-biphenyl)-2,4'-diol 
• 35354-74-6 Honokiol 

Relevant academic research and scientific papers

A concise synthetic approach to dihydrochalcone: First total syntheses of bipinnatone A and B

The first total syntheses of bipinnatone A and B have been achieved starting from commercially available phloroglucinol, p-hydroxybenzaldehyde in ten steps. Key features of the syntheses include Aldol reaction, aryl-alkylation and InCl3-NaBH4 selective reduction.

Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan

Honokiol, a biphenyl-type neolignan, which shows the remarkable neurotrophic effect in primary cultured rat cortical neurons, has been effectively synthesized in 21% yield over 14 steps starting from 5-bromosalicylic acid and p-hydroxybenzoic acid by utilizing Pd-catalyzed Suzuki-Miyaura coupling reaction as a key step. Additionally, the structure-activity relationship between neurite outgrowth-promoting activity and its O-methylated and/or its hydrogenated analogues was examined in the primary cultures of fetal rat cortical neurons, suggesting that 5-allyl and 4′-hydroxyl groups are essential for affecting the neurotrophic activity of honokiol.