219583-73-0Relevant articles and documents
CYCLOPENTYLBENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PSYCHOTIC AND COGNITIVE DISORDERS
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Page/Page column 54; 55, (2015/05/05)
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein n, L, X, Ra, Rb, R1, R2 and R3 their preparation, pharmaceutical compositions containing them and their use in therapy.
Copper-catalyzed domino homologation and cycloisomerization reactions for 3-pyrroline synthesis
Shin, Ye Ho,Maheswara, Muchchintala,Hwang, Joon Young,Kang, Eun Joo
, p. 2305 - 2311 (2014/04/17)
Copper bromide was found to be an efficient catalyst for a domino reaction sequence leading to 3-pyrrolines. The Cu(I)-catalyzed Crabbe reaction of propargyl sulfonamide and selective cycloisomerization of the allene intermediate were carried out using microwave irradiation conditions affording a wide range of 2-substituted- and 2,5-disubstituted-3-pyrrolines. Mechanistic studies of the reaction intermediates revealed two possible reaction pathways; both invoke the importance of vinyl copper intermediates.
A fluorous-tagged linker from which small molecules are released by ring-closing metathesis
Leach, Stuart G.,Cordier, Christopher J.,Morton, Daniel,McKiernan, Gordon J.,Warriner, Stuart,Nelson, Adam
, p. 2753 - 2759 (2008/09/19)
(Chemical Equation Presented) A fluorous-tagged linker for the parallel synthesis of small- and medium-ring and macrocyclic nitrogen heterocycles using ring-closing metathesis is described. The linker was designed such that "cyclization-release" of the cyclic heterocyclic products was coupled with liberation of the active catalyst. The design of the linker was validated using a non-fluorous-tagged model. A wide range of unsaturated alcohols were used as reagents to functionalize afluorous-tagged sulfonamide, (Z)-{N-[4-(2-(N′-3,3,4,4,5,5,6,6,7,7,8,8,9,9,-10,10,10- heptadecafluorodecyl)-4-methylsulfonamido)methylallyloxy]but-2-enyl} -2-nitrobenzene-sulfonamide, using Fukuyama-Mitsunobu reactions; in each case, fluorous-solid-phase extraction (F-SPE) was used to purify the functionalized linker from the excess reagents. In general, the "cyclization-release" of cyclic products was triggered using a light-fluorous tagged derivative of the Grubbs-Hoveyda second-generation catalyst. After the metathesis step, F-SPE was used to purify released cyclic compounds from the fluorous-tagged linker and the fluorous-tagged catalyst. The scope and limitations of the approach were determined using a range of substrates which probed different aspects of the functionalization and metathesis steps. In the study as a whole, a wide range of small- and medium-ring and macrocyclic nitrogen heterocycles were prepared using polyene and polyenyne metathesis cascades.
NOVEL ADENOSINE A3 RECEPTOR AGONISTS
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Page/Page column 63-64, (2008/06/13)
The invention realizes that a series of sulfonamido derivatives with a conserved uronamide group at the 5' position provide superior A3 receptor affinity as well as selectivity. These new adenosine agonists are sulfonamido deritatives N-substituted with aliphatic groups (cyclic or linear) or aromatic radicals.
Palladium(0)-catalyzed allylation of highly acidic and non-nucleophilic arenesulfonamides, sulfamide, and cyanamide. I.
Cerezo, Silvia,Cortes, Jordi,Moreno-Manas, Marcial,Pleixats, Roser,Roglans, Anna
, p. 14869 - 14884 (2007/10/03)
Arenesulfonamides, sulfamide, and cyanamide are efficiently allylated using allylic carbonates under Pd(0)-catalysis. N-Arenesulfonyl-2,5- dihydropyrroles are obtained by ruthenium-mediated ring closing metathesis of the corresponding N-diallylated compounds. A stereochemical study of the reactions of ethyl cis-(5-methyl-2-cyclohexenyl) carbonate with 2,4,6- triisopropylphenylsulfonamide was performed, clean overall retention of configuration being found with bidentate phosphines.
