51144-95-7

Upstream product

• 109-97-7 pyrrole 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 5455-59-4 2-Nitrobenzenesulfonamide 
• 219583-73-0 1-[(2-nitrobenzene)sulfonyl]-2,5-dihydro-1H-pyrrole 

Downstream Products

• 1403229-98-0 C₁₄H₁₄N₂O₅S₂ 
• 1403229-99-1 N-nosyl-8-azabicyclo[3.2.1]oct-6-en-3-one 
• 1403230-11-4 N-nosyl-2,2-dimethyl-8-azabicyclo[3.2.1]oct-6-en-3-one 
• 54254-41-0 1-(2-aminobenzenesulfonyl)-1H-pyrrole 

Relevant academic research and scientific papers

A ring closing metathesis-manganese dioxide oxidation sequence for the synthesis of substituted pyrroles

The combination of ring closing, or enyne metathesis with oxidation in order to prepare N-sulfonyl pyrroles is described. Reasonable to good yields were obtained for a variety of substituents and the procedure may also be conducted in one-pot. 2-Bromo N-sulfonyl adducts prepared in this manner were subjected to an intramolecular Heck-type cyclisation, forming cyclic sulfonamides.

Concise [4+3] cycloaddition reaction of pyrroles leading to tropinone derivatives

A concise [4+3] cycloaddition reaction of pyrroles with 2-(silyloxy)allyl cations has been developed. The oxyallyl cations stabilized with a methylthio group or geminal methyl groups were generated from the corresponding allylic alcohols under the influence of a Br?nsted acid (Tf2NH), respectively. The use of N-nosyl-protected pyrroles as the four-carbon unit was found to give tropinone derivatives in high yield.

Benzodiazepine Derivatives and Uses Thereof on Medical Field

The invention concerns benzodiazepine derivatives of formula wherein Y it is SO2 or NR, wherein R is H or C1-C6 alkyl; X is H, C1-C12 alkyl, —CO, —SO, —SO2, or —CO—R2, SO—R2

BENZODIAZEPINE DERIVATIVES AND USES THEREOF IN MEDICAL FIELD

The invention concerns benzodiazepine derivatives of formula (I) wherein Y it is SO2 or NR, wherein R is H or C1-C6 alkyl; X is H, C1-C12 alkyl, -CO, -SO, -SO2, or - CO-R2, SO-R

Synthesis of pyrryl aryl sulfones targeted at the HIV-1 reverse transcriptase

Various aryl 1-pyrryl sulfones were synthesized and tested as inhibitors of HIV-1. 2-Nitrophenyl-2-ethoxycarbonyl-1-pyrryl sulfone, the most active among test derivatives, was selected as lead compound of the aryl pyrryl sulfone series. The in vitro anti-