219627-06-2

Upstream product

• 399024-22-7 (2S,3S,4R,5R)-3,4-Bis-benzyloxy-2-octyloxy-5-trityloxymethyl-tetrahydro-furan 
• 111-87-5 octanol 
• 100-39-0 benzyl bromide 
• 219627-21-1 octyl 2,3,5-tri-O-acetyl-α-D-arabinofranose tetraacetate 
• 352438-36-9 octyl α-D-arabinofranose tetraacetate 
• 396134-85-3 octyl 5-O-trityl-α-D-arabinofranose tetraacetate 
• 61826-42-4 tetra-O-acetyl-D-arabinofuranose 

Downstream Products

• 219627-25-5 octyl 5-O-(2,3,5-tri-O-acetyl-α-D-lyxofuranosyl)-2,3-di-O-benzyl-α-D-arabinofuranoside 
• 367921-22-0 octyl 5-O-(2,3,5-tri-O-benzoyl-α-D-arabinofuranosyl)-2,3-di-O-benzyl-α-D-arabinofuranoside 
• 396134-86-4 octyl 5-O-(α-D-arabinofuranosyl)-2,3-di-O-benzyl-α-D-arabinofuranoside 

Relevant academic research and scientific papers

Studies on α(1→5) linked octyl arabinofuranosyl disaccharides for mycobacterial arabinosyl transferase activity

The appearance multi-drug resistant Mycobacterium tuberculosis (MTB) throughout the world has prompted a search for new, safer and more active agents against tuberculosis. Based on studies of the biosynthesis of mycobacterial cell wall polysaccharides, octyl 5-O-(α-D-arabinofuranosyl)-α-D-arabinofuranoside analogues were synthesized and evaluated as inhibitors for M. tuberculosis and Mycobacterium avium. A cell free assay system has been used for the evaluation of these disaccharides as substrates for mycobacterial arabinosyltransferase activity.

A facile method for deprotection of trityl ethers using column chromatography

A mild, efficient and inexpensive detritylation method is reported that uses trifluoroacetic acid on a silica gel column to obtain pure, detritylated compounds in one-step. This method is applicable to acid stable as well as acid sensitive compounds with only slight alterations in the procedure. Nineteen examples are given.