219649-70-4Relevant academic research and scientific papers
Synthesis of 4'-trifluoromethyl nucleoside analogs
Kozak, Janusz,Johnson, Carl R.
, p. 2221 - 2239 (1998)
A strategy based on the use of (trifluoromethyl)trimethylsilane for introduction of the trifluoromethyl group at the C-4 of ribose has been developed and utilized in the synthesis of various novel 4'- trifluoromethylated nucleoside analogs. Screening of these analogs against HIV did not reveal significant biological activity.
