Synthesis of 4'-trifluoromethyl nucleoside analogs

Article abstract of DOI:10.1080/07328319808004312

A strategy based on the use of (trifluoromethyl)trimethylsilane for introduction of the trifluoromethyl group at the C-4 of ribose has been developed and utilized in the synthesis of various novel 4'- trifluoromethylated nucleoside analogs. Screening of these analogs against HIV did not reveal significant biological activity.

Full text of DOI:10.1080/07328319808004312

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Nucleosides and Nucleotides
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Synthesis of 4′-Trifluoromethyl
Nucleoside Analogs
Janusz Kozak a & Carl R. Johnson a
a Department of Chemistry, Wayne State University, Detroit,
Michigan, 48202-3489
Version of record first published: 16 Aug 2006.
To cite this article: Janusz Kozak & Carl R. Johnson (1998): Synthesis of 4′-Trifluoromethyl Nucleoside
Analogs, Nucleosides and Nucleotides, 17:12, 2221-2239
To link to this article: http://dx.doi.org/10.1080/07328319808004312
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