219685-47-9Relevant academic research and scientific papers
Discovery of novel bromophenol hybrids as potential anticancer agents through the ros-mediated apoptotic pathway: Design, synthesis and biological evaluation
Wang, Li-Jun,Guo, Chuan-Long,Li, Xiang-Qian,Wang, Shuai-Yu,Jiang, Bo,Zhao, Yue,Luo, Jiao,Xu, Kuo,Liu, Hua,Guo, Shu-Ju,Wu, Ning,Shi, Da-Yong
, (2017)
A series of bromophenol hybrids with N-containing heterocyclic moieties were designed, and their anticancer activities against a panel of five human cancer cell lines (A549, Bel7402, HepG2, HCT116 and Caco2) using MTT assay in vitro were explored. Among t
Antibacterial and antioxidant activity evaluation of novel symmetrical and unsymmetrical C5-curcuminoids
Manohar, Sunny,Thakur, Anuj,Bhatia, Rohit,Walia, Suresh,Ponnan, Prija,Rawat, Diwan S.
, p. 1235 - 1246 (2015/11/24)
Curcumin remains one of the most widely studied natural product due to its wide range of biological activities but because of the presence of central β-diketone unit which is responsible for its poor bioavailability, this molecule cannot be developed as a drug. In order to overcome this, curcumin has been modified to metabolically stable symmetrical and unsymmetrical C5-curcuminoids and their in vitro antibacterial and antioxidant activity were studied. Few of the synthesized C5-curcuminoids (10, 11 and 25) displayed excellent potency (MIC value 1.5 to 6.25 μg/mL) against the tested bacterial strains. Six of the analogues (10, 12-15 and 25) were also found to exhibit good antioxidant activity (IC50 values 33.87 to 49.45 μg/mL) in a DPPH free radical scavenging assay. The test compounds have been further subjected to in silico ADMET analysis and various pharmacokinetic properties were calculated. Compounds 20, 23-25 are predicted to have less toxic effects and follow the permissible pharmacokinetic criterion.
Glucagon antagonists/inverse agonists
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, (2008/06/13)
Non-peptide compounds comprising a central hydrazide motif and methods for the synthesis thereof are disclosed. The compounds act to antagonize the action of the glucagon peptide hormone.
