219686-43-8

Basic information

• Product Name: 7-BROMO-1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE
• Synonyms: 7-BROMO-1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE;7-broMo-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one
• CAS NO: 219686-43-8
• Molecular Formula: C9H9BrN2O
• Molecular Weight: 241.08
• Mol File: 219686-43-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 7-BROMO-1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-BROMO-1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE(219686-43-8)
• EPA Substance Registry System: 7-BROMO-1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE(219686-43-8)

Safety Data

• Hazardous Substances Data: 219686-43-8(Hazardous Substances Data)

Usage

General Description

7-Bromo-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one is a chemical compound with a molecular formula C9H9BrN2O. It is a heterocyclic compound that belongs to the benzodiazepine class of drugs. 7-BROMO-1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE has potential applications in the field of pharmacology and medicine due to its ability to modulate the activity of gamma-aminobutyric acid (GABA) receptors in the central nervous system, resulting in sedative, anxiolytic, muscle relaxant, and anticonvulsant properties. It is important for researchers and pharmaceutical companies to study and understand the effects and potential therapeutic uses of 7-Bromo-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one in order to develop new drugs for the treatment of various neurological and psychiatric disorders.

Upstream product

• 1407832-73-8 methyl 3-((2-amino-5-bromophenyl)amino)propanoate 
• 1407832-71-6 methyl 3-((5 -bromo-2-nitrophenyl)amino)propanoate 
• 321-23-3 4-bromo-2-fluoronitrobenzene 
• 219686-36-9 5-trifluoroacetyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one 
• 5755-07-7 2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one 
• 219686-38-1 7-bromo-5-trifluoroacetyl-2,3,4,5-tetrahydro-1,5-benzodiazepin-2(1H)-one 

Relevant articles and documents

Convenient synthesis of 7-bromo-tetrahydro-1,5-benzodiazepin-2-ones

Treatment of 5-acyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-ones with bromine in the presence of the sulfuric acid afforded products to be brominated exclusively in the aromatic ring at position 7.

Discovery of Benzotriazolo[4,3-d][1,4]diazepines as Orally Active Inhibitors of BET Bromodomains

Inhibition of the bromodomains of the BET family, of which BRD4 is a member, has been shown to decrease myc and interleukin (IL) 6 in vivo, markers that are of therapeutic relevance to cancer and inflammatory disease, respectively. Herein we report substituted benzo[b]isoxazolo[4,5-d]azepines and benzotriazolo[4,3-d][1,4]diazepines as fragment-derived novel inhibitors of the bromodomain of BRD4. Compounds from these series were potent and selective in cells, and subsequent optimization of microsomal stability yielded representatives that demonstrated dose- and time-dependent reduction of plasma IL-6 in mice.