219689-99-3

Basic information

• Product Name: 5,7-dihydroxy-2-(methoxymethyl)-4H-chromen-4-one
• Synonyms: 5,7-dihydroxy-2-(methoxymethyl)-4H-chromen-4-one
• CAS NO: 219689-99-3
• Molecular Weight: 222.197
• Mol File: 219689-99-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5,7-dihydroxy-2-(methoxymethyl)-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-dihydroxy-2-(methoxymethyl)-4H-chromen-4-one(219689-99-3)
• EPA Substance Registry System: 5,7-dihydroxy-2-(methoxymethyl)-4H-chromen-4-one(219689-99-3)

Safety Data

• Hazardous Substances Data: 219689-99-3(Hazardous Substances Data)

Upstream product

• 4128-76-1 methoxy acetic acid dimethylamide 
• 480-66-0 2,4,6-trihydroxyacetophenone 

Downstream Products

• 64519-22-8 norcimifugin 

Relevant articles and documents

An antiinflammatory active furochromone, norcimifugin from Cimicifuga foetida: Isolation, characterization, total synthesis and antiinflammatory activity of its Analogues

In the course of our investigation to isolate the non-steroidal antiinflammatory active (NSAIA) lead molecules from the plants, 1 [(2S)-4-hydroxy-7-hydroxymethyl-2-(1-hydroxy-l-methylethyl)-2,3-dihydro-5H- oxolo[3′2′:4,5]-benzo [b]oxin-5-one also called as norcimifugin] has been isolated from the dichloromethane extract of rhizomes of Cimicifuga foetida. Characterization, total synthesis and antiinflammatory activity of 1 are reported. Alkyl, ester, carbamate, amine derivatives of 1 have been synthesized and their antiinflammatory activity assessed. Norcimifugin displayed antiinflammatory activity in the carrageenin induced paw edema model (50.4% inhibition at 50 mg/kg, p.o.).