219708-64-2

Upstream product

• 219708-57-3 3-[3-(tert-Butyl-dimethyl-silanyloxy)-2-(2-methoxy-phenyl)-propyl]-4-hydroxy-oxazolidin-2-one 
• 219708-53-9 3-[3-(tert-Butyl-dimethyl-silanyloxy)-2-(2-methoxy-phenyl)-propyl]-oxazolidine-2,4-dione 
• 219708-51-7 3-(tert-Butyl-dimethyl-silanyloxy)-2-(2-methoxy-phenyl)-propan-1-ol 
• 20730-59-0 2-(2-methoxyphenyl)-1,3-propanediol 
• 60779-18-2 Methyl-o-carbomethoxymethoxyphenylacetat 
• 219708-61-9 3-[3-(tert-Butyl-dimethyl-silanyloxy)-2-(2-methoxy-phenyl)-propyl]-4-phenylsulfanyl-oxazolidin-2-one 

Downstream Products

• 219708-70-0 [(E)-3-(2-Methoxy-phenyl)-4-(2-oxo-4-phenylsulfanyl-oxazolidin-3-yl)-but-1-enyl]-phosphonic acid diethyl ester 
• 219708-67-5 2-(2-Methoxy-phenyl)-3-(2-oxo-4-phenylsulfanyl-oxazolidin-3-yl)-propionaldehyde 

Relevant academic research and scientific papers

Diastereoselective synthesis of ω-phosphonic acid analogues of 4-arylkainoids

Radical cyclisation by the use of α,β-unsaturated phosphonate as a radical acceptor was applied to a synthesis of 7-phosphonomethylpyrrolo[1,2-c]oxazolidinones, synthetic intermediates on the route to phosphonic acid analogues of kainoids. The relative configuration at the 6;7;7a-positions was found to be highly controlled by steric effects due to the substituent at the 6-position. Thus, diethyl [{(6S*,7R*,7aS*)-6-(2-methoxyphenyl)-3-oxoperhydropyrrolo[1,2- c]-[1,3]oxazol-7-yl}methyl]phosphonate 29a and diethyl [{(6S*,7R*,7aS*)-3-oxo-6-phenylperhydropyrrolo[1,2-c][1,3]- oxazol-7-yl}methyl]phosphonate 29b were prepared with high diastereoselectivity. When the substituent at the 6-position is a 1-naphthyl group, the diethyl [{(6S*,7R*,7aS*)-6-(1-naphthyl)pyrroloxazol-7-yl}methyl] phosphonate 29c and its (6S*,7R*,7aR*)-isomer 30c were formed in the ratio 29c:30c～2:1. The stereostructure of compound 29a was determined by X-ray crystallographic analysis. The 6-o-methoxyphenyl derivative 29a was converted into the corresponding phosphonic acid analogue 33.