219740-20-2Relevant articles and documents
Synthesis and evaluation of artificial taxoids with antitumor and multi- drug resistance reversing activities
Morihira, Koichiro,Nishimori, Toshiyuki,Kusama, Hiroyuki,Horiguchi, Yoshiaki,Kuwajima, Isao,Tsuruo, Takashi
, p. 2977 - 2982 (2007/10/03)
Artificial taxoids were synthesized and subjected to evaluation of their ability of multi-drug resistance reversing and antitumor activities. While the taxoid 4 could not increase cellular accumulation of vincristine in multi-drug resistant tumor cells, the C4-hydroxy analog 15 showed significant effect. However, these compounds showed weak activities on growth inhibition of cancer cells.