219739-99-8

Upstream product

• 162084-46-0 (S)-1-Hydroxy-4,6,6-trimethyl-5-[1-phenylsulfanyl-meth-(E)-ylidene]-3-triisopropylsilanyloxy-cyclohex-3-enecarbaldehyde 

Downstream Products

• 219740-25-7 C₆₄H₈₅NO₁₁SSi₂ 
• 219740-20-2 C₆₂H₈₃NO₁₀SSi₂ 
• 219740-15-5 Benzoic acid (1S,2S,4S,9R,10R,13S)-9-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-1,4,13-trihydroxy-4,12,15,15-tetramethyl-10-phenylsulfanyl-tricyclo[9.3.1.0^3,8]pentadeca-3⁽⁸⁾,11-dien-2-yl ester 
• 219740-11-1 C₃₄H₅₀O₇SSi 
• 219740-05-3 C₃₃H₄₄O₇SSi 
• 219740-40-6 (1S,2S,9R,10R)-9-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxy]-1,2-dihydroxy-12,15,15-trimethyl-10-phenylsulfanyl-tricyclo[9.3.1.0^3,8]pentadeca-3⁽⁸⁾,11-diene-4,13-dione 
• 219740-36-0 3-[1,3]Dioxolan-2-yl-2-((S)-hydroxy-{(S)-1-hydroxy-4,6,6-trimethyl-5-[1-phenylsulfanyl-meth-(E)-ylidene]-3-triisopropylsilanyloxy-cyclohex-3-enyl}-methyl)-cyclohex-2-enone 

Relevant academic research and scientific papers

Synthesis and evaluation of artificial taxoids with antitumor and multi- drug resistance reversing activities

Artificial taxoids were synthesized and subjected to evaluation of their ability of multi-drug resistance reversing and antitumor activities. While the taxoid 4 could not increase cellular accumulation of vincristine in multi-drug resistant tumor cells, the C4-hydroxy analog 15 showed significant effect. However, these compounds showed weak activities on growth inhibition of cancer cells.