219763-82-3

Basic information

• Product Name: 4-HYDROXY-6-CYANOQUINOLINE
• Synonyms: 4-HYDROXY-6-CYANOQUINOLINE;4-oxo-1H-quinoline-6-carbonitrile
• CAS NO: 219763-82-3
• Molecular Formula: C10H6N2O
• Molecular Weight: 170.17
• Mol File: 219763-82-3.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-HYDROXY-6-CYANOQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-6-CYANOQUINOLINE(219763-82-3)
• EPA Substance Registry System: 4-HYDROXY-6-CYANOQUINOLINE(219763-82-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 219763-82-3(Hazardous Substances Data)

Usage

General Description

4-Hydroxy-6-cyanoquinoline is a chemical compound that belongs to the class of quinoline derivatives. It is a yellow crystalline solid with a molecular formula of C10H6N2O and a molecular weight of 174.17 g/mol. 4-HYDROXY-6-CYANOQUINOLINE is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various organic compounds and pharmaceuticals. It also exhibits potential biological activity and has been studied for its antimalarial and anticancer properties. Additionally, 4-hydroxy-6-cyanoquinoline is used in chemical research and as a reagent in organic synthesis. However, it is important to handle this compound with caution as it may be harmful if ingested, inhaled, or in contact with skin, and proper safety precautions should be taken when handling it.

Upstream product

• 219763-81-2 4-[(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-benzonitrile 
• 873-74-5 4-Aminobenzonitrile 
• 2033-24-1 cycl-isopropylidene malonate 

Downstream Products

• 219763-87-8 4-bromoquinoline-6-carboxylic acid 
• 219763-85-6 4-bromoquinoline-6-carboxylic acid methyl ester 
• 642477-82-5 4-bromoquinoline-6-carbonitrile 
• 219763-83-4 4-chloroquinoline-6-carbonitrile 

Relevant articles and documents

A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics

Senexins are potent and selective quinazoline inhibitors of CDK8/19 Mediator kinases. To improve their potency and metabolic stability, quinoline-based derivatives were designed through a structure-guided strategy based on the simulated drug–target dockin

Application of Pd-Catalyzed Cross-Coupling Reactions in the Synthesis of 5,5-Dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles that Inhibit ALK5 Kinase

C-H activation of position 3 of a substituted pyrazole ring catalyzed by palladium(II) was straightforward and convenient for arylated or heteroarylated 5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles. Moreover, we introduced simple protection of the nitrogen in the pyridin-2-yl directing group, which otherwise does not allow a cross-coupling reaction, by transformation to the N-oxide. Selected final products were reasonably selective ALK5 kinase inhibitors.

Highly efficient thermal cyclization reactions of alkylidene esters in continuous flow to give aromatic/heteroaromatic derivatives

Intramolecular thermal cyclization and benzannulation reactions of the Gould-Jacobs and Conrad-Limpach types were performed in a designed continuous flow reactor system at temperatures in the range of 300-360°C and under high pressure conditions (100-160 bar) with very short residence times (0.45-4.5 min) in tetrahydrofuran as a low-boiling point solvent. Substituted heteroaromatic compounds including pyridopyrimidinones and hydroxyquinolines were synthesized in moderate to high yields. Application of the reaction conditions also allows the synthesis of naphthol and biphenyl derivatives. The procedure involves an easy work-up and the non-batchwise preparative synthesis method is suitable for automation.