219765-01-2

Upstream product

• 52301-88-9 (2-chloro-4-nitrophenyl)methanol 
• 219762-28-4 5-bromo-2-methyl-3H-imidazo[4,5-b]pyridine 
• 219763-98-1 methyl 2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylate 
• 219764-99-5 2-chloro-1-((methanesulfonyloxy)methyl)-4-nitrobenzene 
• 219765-00-1 methyl 3-(2-chloro-4-nitrobenzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylate 
• 144-55-8 sodium hydrogencarbonate 

Downstream Products

• 219767-90-5 methyl 3-(2-chloro-4-(N-(n-pentyl)amino)benzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylate 
• 219767-82-5 methyl 3-(4-(N-butyrylamino)-2-chlorobenzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylate 
• 275383-29-4 methyl 3-[4-(N,N-bis-(tert-butoxycarbonyl)-amino)-2-chlorobenzyl]-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylate 
• 275383-35-2 methyl 3-(4-(N-(1-butanesulfonyl)amino)-2-chlorobenzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylate 
• 275383-52-3 methyl 3-(2-chloro-4-(3-(n-propyl)ureido)benzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylate 
• 275383-31-8 methyl 3-(2-chloro-4-(ethoxycarbonylamino)benzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylate 
• 275383-26-1 methyl 3-[(5-amino-2,4-dichloro)benzyl]-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylate 
• 275383-17-0 methyl 3-(2-chloro-4-(1-pyrrolyl)benzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylate 
• 275383-30-7 3-(4-(N-(tert-butoxycarbonyl)-amino)-2-chlorobenzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylic acid 
• 275383-27-2 methyl 3-[(2,4-dichloro-5-(N,N-dimethylamino))benzyl]-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylate 

Relevant academic research and scientific papers

Sulfonamide compounds and uses thereof as medicines

The present invention relates to a sulfonamide compound of the formula (I): wherein each symbol is as defined in the specification, a salt thereof, and a pharmaceutical composition containing same. This compound can be an effective agent for the prophylaxis and treatment of the diseases curable based on a hypoglycemic action, and the diseases curable based on a cGMP-PDE inhibitory action, a smooth muscle relaxing action, a bronchodilating action, a vasodilating action, a smooth muscle cell inhibitory action and an allergy suppressing action.

Sulfonamide compounds and medicinal use thereof

A sulfonamide compound of the formula (I):R 1 --SO 2 NHCO--A--R 2 (I)wherein R 1 is alkyl, alkenyl, alkynyl and the like; A is an optionally substituted heteropolycyclic group except benzimidazolyl, indolyl, 4,7-dihydrobenzimidazolyl and 2,3-dihydrobenzoxazinyl; X is alkylene, oxa, oxa(lower)alkylene and the like; and R 2 is optionally substituted aryl, substituted biphenylyl and the like, a salt thereof and a pharmaceutical composition comprising the same. The sulfonamide compound is effective for the diseases treatable based on their blood sugar level-depressing activity, cGMP-PDE (especially PDE-V)-inhibiting activity, smooth muscle relaxing activity, bronchodilating activity, vasodilating activity, smooth muscle cell suppressing activity, and antiallergic activity.